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An independent reference cataloguing nootropics, peptides, research chemicals and pharmaceuticals; what each compound is, how it works, and what it is used or studied for.

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Dihexapeptide

Dihexa is a small angiotensin IV analogue engineered at Washington State University to do something most peptides cannot, which is survive oral dos…

bindsHGF / c-Met

4 sourcesRead more

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the obscure end of the catalogue; compounds almost nobody looks up, and the ones the nootropics world has quietly skipped.

Ophtalaminbioregulator1 outlet
Ovariaminbioregulator1 outlet
Pentalgin Neoanalgesic1 outlet
R-Alpha Lipoic Acid with Biotinsupplement1 outlet
Suprefortbioregulator1 outlet
Suprenaminbioregulator1 outlet
Svetinormbioregulator1 outlet
Testalaminbioregulator1 outlet
AZD-3783serotonergic
Galanin(2-11)peptide

rarely looked up; sourced but overlookedthe full archive

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new here? start with the plain-English explainers behind the compounds; what the terms actually mean, with citations.

Adaptogens & the stress responseWhere the word came from, why the definition resists testing, what the modern randomised trials actually found.

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2023 compounds in total; 980 with sourcing; use a filter or scroll to view

Nootropics· 20

MNT (pmp) blend

MNT (PMP) is a combination injectable and pre-workout formula that pairs nitric oxide precursors with a focused cognitive stack in a single shot. Arginine, citrulline, and the arginase inhibitor norvaline drive vasodilation and blood flow for a stronger pump, while citicoline, N-acetyl-L-tyrosine, and trimethylglycine sharpen focus and support drive under load. It is engineered as a two-in-one performance blend th…

bindsNitric oxide pathway (eNOS substrate)

1 sourceNitric oxide synthase

RGPU-95 racetam

RGPU-95 is an experimental compound studied in Russian pharmacological research as a structural analog of fenotropil, better known as phenylpiracetam, a nootropic of the racetam family. In animal experiments it has shown anxiety-reducing and antidepressant-like effects, in some measures exceeding those of its parent compound. It is an obscure investigational substance with essentially no human data, and it is not…

bindsDopamine transporter (DAT)

1 sourceDopamine

Dihexa peptide★

Dihexa is a small angiotensin IV analogue engineered at Washington State University to do something most peptides cannot, which is survive oral dosing and cross into the brain. Where most cognitive compounds nudge neurotransmitter levels, it was designed to act on the machinery that physically builds connections between neurons, and the preclinical reports are striking: reversed amnesia in animal models, restored…

bindsHGF / c-Met

4 sourcesNeurotrophins

Semax peptide★

Semax is a synthetic peptide nootropic and neuroprotective agent based on a fragment of adrenocorticotropic hormone (ACTH), developed in Russia and used there clinically for cognition, stroke, and brain injury. It rapidly raises the brain's own growth factors, BDNF and NGF, and modulates dopamine and serotonin, underpinning its reputation for sharper focus, memory, and mental drive. Delivered as a nasal spray and…

bindsBDNF / TrkB

7 sourcesNeurotrophins

Selank peptide★

Selank is a synthetic peptide anxiolytic and nootropic derived from the immune peptide tuftsin, developed in Russia as a non-sedating, non-addictive alternative to conventional anti-anxiety drugs. It eases anxiety while supporting memory and attention, and animal research links these effects to modulation of GABA, serotonin, and brain-derived neurotrophic factor. Typically given as a nasal spray, it offers calm an…

bindsTuftsin / immune peptide pathway

7 sourcesGABA

Cerebrolysin peptide★

Cerebrolysin is a neuropeptide preparation that mimics the brain's own neurotrophic factors to support neuronal protection, repair, and plasticity. Widely used across Europe and Asia for stroke, dementia, and traumatic brain injury, it is one of the most established neurotrophic therapies in clinical practice. For those focused on brain health and neuroregeneration, Cerebrolysin is a uniquely biologically active p…

bindsNeurotrophic factors (BDNF / NGF-like)

4 sourcesNeurotrophins

P21 peptide★

P21 (P021) is a small, orally active neurotrophic peptide mimetic derived from ciliary neurotrophic factor, engineered to deliver the brain-building benefits of a neurotrophic factor without the drawbacks that stalled earlier protein therapies. It enhances hippocampal neurogenesis and raises BDNF while lowering the tau-driving kinase GSK-3beta, and in Alzheimer's models it reduced tau pathology and rescued cogniti…

bindsBDNF / TrkB

2 sourcesNeurotrophins

PE-22-28 peptide★

PE-22-28 is a fast-acting mood peptide with a genuinely clever mechanism, engineered from the natural antidepressant peptide spadin to be more potent and stable. It blocks the TREK-1 potassium channel that sits in mood circuits and dampens serotonin signaling, and animals bred without TREK-1 are naturally resistant to depression [2]. In rodent studies its shortened design achieved dramatically stronger TREK-1 inhi…

bindsTREK-1 potassium channelIC50 0.12 nM

4 sourcesSerotonin

Adamax peptide★

Adamax is a research peptide built from Semax by capping it with an adamantane group, a bulky lipophilic cage intended to improve stability and passage into the brain. No published study examines Adamax itself, so everything on this page about how it works is reasoned from the Semax literature rather than measured for this compound; the claim that it is more potent than its parent has never been tested. For reader…

bindsBDNF / TrkB

2 sourcesNeurotrophins

Noopept memory★

Noopept is one of the most extensively researched dipeptide nootropics, a proline-containing compound designed as a peptide analog of piracetam with far greater potency by weight. Its standout quality is neuroprotection; in cellular models it guarded neurons against oxidative and amyloid-related damage more effectively than piracetam or classic antioxidants, while attenuating tau hyperphosphorylation [1][3]. Studi…

bindsBDNF / NGF

3 sourcesNeurotrophins

Phenylpiracetam racetam★

Phenylpiracetam (phenotropil, carphedon) is a phenylated derivative of piracetam, developed in Russia and used clinically as a nootropic, with reported effects on focus, physical endurance, and tolerance to cold and fatigue. The added phenyl group makes it considerably more potent than the parent racetam and confers a distinct mechanism, selective inhibition of the dopamine transporter, which is thought to underli…

bindsα4β2 nicotinic ACh receptor

3 sourcesAcetylcholine

Amphetamine adhd

Amphetamine is a potent central nervous system stimulant and the parent compound of a broad family of related drugs. In medicine it is used chiefly to treat attention-deficit hyperactivity disorder (ADHD) and narcolepsy, where it improves attention, wakefulness, and impulse control by raising the brain's levels of the neurotransmitters dopamine and norepinephrine [1]. It also has a long history of recreational mis…

bindsDopamine transporter (DAT)IC50 ~960 nM

referenceDopamine

Dexmethylphenidate adhd

Dexmethylphenidate is a central nervous system stimulant used to treat attention deficit hyperactivity disorder (ADHD). It is the more active of the two mirror-image forms of methylphenidate, specifically the d-threo enantiomer, and is sold under the brand name Focalin in immediate-release and extended-release forms. By blocking the reuptake of dopamine and norepinephrine, it raises the availability of these neuro…

bindsDopamine transporter (DAT)the d-enantiomer carries essentially all of methylphenidate's reuptake-blocking potency; the l-isomer is near-inactive here

referenceDopamine

Dextroamphetamine adhd

Dextroamphetamine is a central nervous system stimulant and the more active of the two mirror-image forms of amphetamine. It is used mainly to treat attention deficit hyperactivity disorder (ADHD) and narcolepsy, and it forms the active component of several widely prescribed medicines, including Dexedrine, the mixed-salt product Adderall, and the prodrug lisdexamfetamine. The drug works by increasing the release a…

bindsDopamine transporter (DAT)Ki ~109 nM

referenceDopamine

HBT1 ampakine

HBT1 is a positive allosteric modulator of the AMPA receptor (an "ampakine") that came out of a Takeda drug-discovery program. Its selling point is a gentler profile than earlier ampakines; it has low intrinsic agonist activity and works mostly only when the brain's own glutamate is present, which let it raise BDNF (brain-derived neurotrophic factor, a key growth signal for neurons) in lab neurons without the bell…

bindsAMPA receptor

referenceGlutamate (AMPA)

Lisdexamfetamine adhd

Lisdexamfetamine is a central nervous system stimulant used to treat attention-deficit hyperactivity disorder (ADHD) and moderate-to-severe binge eating disorder. It is a prodrug of dextroamphetamine, meaning it is inactive until the body converts it into the active stimulant, which gives it a smooth, long-lasting effect. Sold mainly under the brand name Vyvanse, it is a once-daily oral medicine and a controlled s…

bindsRed blood cell hydrolysis (prodrug activation)

referenceDopamine

Methylphenidate adhd

Methylphenidate is a central nervous system stimulant widely used to treat attention-deficit hyperactivity disorder (ADHD) and narcolepsy. Sold under brand names such as Ritalin and Concerta, it works by blocking the reuptake of the neurotransmitters dopamine and norepinephrine, raising their levels in the brain and improving attention and impulse control. First synthesized in the 1940s, it is one of the most comm…

bindsDopamine transporter (DAT)IC50 ~17 nM

referenceDopamine

Serdexmethylphenidate adhd

Serdexmethylphenidate is a prodrug of the stimulant dexmethylphenidate, created by attaching the amino acid serine to the active drug so that it is only slowly converted to its active form in the gastrointestinal tract. It is used to treat attention-deficit/hyperactivity disorder (ADHD) and is marketed in the United States as part of the combination capsule Azstarys, which pairs it with a small amount of immediate…

bindsProdrug cleavage (lower GI tract)

referenceDopamine

Viloxazine adhd

Viloxazine, sold as extended-release Qelbree, is a non-stimulant ADHD medication approved for children, adolescents, and adults. It works mainly as a norepinephrine reuptake inhibitor with additional serotonergic modulation and is not a controlled substance; however, it carries an FDA boxed warning for suicidal thoughts and behaviors and is a strong CYP1A2 inhibitor with important drug interactions.

bindsNorepinephrine transporter (NET)Kd ~155 nM

referenceNorepinephrine

SKF 81297 research chemical

A laboratory reference agonist, not a drug. SKF 81297 is the tool compound researchers reach for when they want to switch on D1-like receptors fully and selectively, and it has never been given to a human [22].

bindsDopamine D1 receptor

referenceDopamine

Available from outlets· 19

5-Amino/MIC blend

5-Amino/MIC is a combination formulation that pairs the NNMT inhibitor 5-Amino-1MQ with the classic lipotropic trio MIC, namely methionine, inositol, and choline. It is designed to attack body fat from two directions at once; 5-Amino-1MQ reprograms fat-cell metabolism by raising NAD, while the MIC lipotropics support the liver's handling and export of fat. Popular in physique and weight-management circles, it bund…

bindsNNMT (nicotinamide N-methyltransferase)

1 sourceFat metabolism

Acetildenafil pde5

Acetildenafil, also known as hongdenafil, is a designer analogue of sildenafil (Viagra) and one of the prototype sildenafil-like PDE5 inhibitors that surfaced in all-natural male-enhancement supplements. Built to mimic sildenafil's blood-flow-boosting mechanism, it delivers erectile-support effects without the branding of a prescription drug, which made it one of the earliest and most widely copied research analog…

bindsPDE5 (phosphodiesterase-5)

1 sourcecGMP

BPC-157/KPV/GHK-Cu Transdermal Serum blend

The BPC-157/KPV/GHK-Cu Transdermal Serum unites three of the most respected regenerative peptides into a single topical formula built for skin, soft tissue, and recovery support. BPC-157 drives angiogenesis and tissue repair, the melanocortin fragment KPV delivers potent anti-inflammatory action, and the copper tripeptide GHK-Cu remodels collagen and rejuvenates the dermal matrix. Together they form a compelling,…

bindsCollagen synthesis / copper delivery (GHK-Cu)

1 sourceWound healing

CJC-1295 / Ipamorelin blend

CJC-1295 / Ipamorelin is a classic synergistic peptide pairing that combines a long-acting GHRH analogue with a highly selective growth hormone secretagogue. Together they stimulate growth hormone release through two complementary pathways, amplifying the natural, pulsatile GH signal cleanly and without raising stress hormones. For those exploring GH-axis support, this stack is among the most refined and popular c…

bindsGHRH receptor

3 sourcesGrowth Hormone

GHK-Cu + Methylene Blue Tallow Balm blend

GHK-Cu + Methylene Blue Tallow Balm is a thoughtfully built topical that stacks three skin-loving actives in a single rub-on jar rather than a needle. The copper peptide GHK-Cu signals collagen and elastin renewal, low-dose methylene blue delivers standout antioxidant and mild antimicrobial support, and a nutrient-rich beef tallow base deeply hydrates while carrying the actives in. For anyone who wants repair, fir…

bindsCollagen / elastin / GAG synthesis (GHK-Cu)

1 sourceCollagen

GLOW blend

GLOW is a smartly built recovery blend that combines three of the best-known repair peptides, GHK-Cu, BPC-157, and TB-500, in a single vial. The logic is elegant; each covers a different slice of the healing process, so together they blanket far more ground than any one peptide could, from collagen and skin quality to tendon repair, blood-vessel growth, and cell migration. For all-around tissue support and recover…

bindsCollagen / Elastin synthesis

4 sourcesCollagen

Herc (mtb) blend

HERC (MTB) is a compounded amino acid blend engineered around the two levers endurance athletes care about most: blood flow and cellular energy. It pairs L-arginine and L-citrulline, which raise nitric oxide to widen vessels and improve muscle oxygenation, with L-carnitine, the carrier that ferries fatty acids into mitochondria for fuel, and L-glutamine for recovery and ammonia handling [1][2][6]. Each component r…

bindsNitric oxide (arginine, citrulline)

1 sourceNitric Oxide

JXL069 dermatological

JXL069 is an experimental mitochondrial pyruvate carrier (MPC) inhibitor developed in the University of California, Los Angeles hair-biology program as a novel metabolic approach to hair loss [1][2]. By blocking pyruvate's entry into mitochondria, it pushes hair follicle stem cells toward glycolysis and lactate production, the metabolic switch that wakes these dormant cells and drives a new hair growth cycle [2].…

bindsMitochondrial pyruvate carrier (MPC1/MPC2)

1 sourceMetabolism

KLOW blend

KLOW is a premium four-peptide recovery blend that unites the celebrated GHK-Cu, BPC-157, and TB-500 trio with the anti-inflammatory tripeptide KPV, addressing skin, gut, and connective-tissue repair alongside inflammation in one formulation. Each component contributes a distinct and complementary mechanism: GHK-Cu drives collagen and skin remodeling, BPC-157 supports tendon, ligament, and gut-lining repair, TB-50…

bindsCollagen / Elastin synthesis

3 sourcesHealing

LGD-4033 + YK-11 blend

LGD-4033 + YK-11 is a research stack that pairs Ligandrol (LGD-4033), a selective androgen receptor modulator, with YK-11, a myostatin-modulating compound, to pursue muscle growth through two mechanisms at once. LGD-4033 activates the androgen receptor and has increased lean body mass in a human trial, while YK-11 raises follistatin to counteract myostatin, the natural brake on muscle growth. For researchers explo…

bindsAndrogen receptor (LGD-4033)Ki ~1 nM

1 sourceMuscle Growth

Lipo MIC Prime blend

Lipo MIC Prime is a lipotropic injectable that combines the classic MIC nutrients (methionine, inositol, and choline) with L-carnitine and vitamin B12 to support fat metabolism and energy during weight management. The MIC compounds help the liver process and export fat, L-carnitine ferries fatty acids into the mitochondria to be burned, and B12 supports energy production and methylation. Bundling several complemen…

bindsHepatic fat handling (choline, inositol)

1 sourceFat metabolism

Lipo-MIC + NAD+ blend

Lipo-MIC + NAD+ is a lipotropic injectable that pairs the fat-metabolizing MIC nutrients (methionine, inositol, and choline) with NAD+, the coenzyme at the center of cellular energy production. The MIC compounds help the liver package and export fat rather than store it, while NAD+ fuels mitochondrial energy metabolism and activates sirtuins involved in fat handling. Combining lipid support with a foundational ene…

bindsCholine / phosphatidylcholine

1 sourceFat Oxidation

Lipo-Nex blend

Lipo-Nex is a lipotropic injectable built around a high-carnitine base combined with choline, inositol, yohimbine, ATP, and vitamin B12, formulated to support fat mobilization and energy. L-carnitine shuttles fatty acids into the mitochondria to be burned, while yohimbine blocks the alpha-2 adrenoceptors that normally restrain fat release, an effect most pronounced in stubborn areas and in the fasted state. With i…

bindsAlpha-2 adrenoceptors (fat cells)

1 sourceFat metabolism

N-Ethyl Tadalafil pde5

N-Ethyl Tadalafil is a designer analog of tadalafil, the long-acting PDE5 inhibitor behind Cialis, built by modifying the original molecule. It is presumed to share tadalafil's ability to relax blood vessels and support erections, and it turns up most often as an undeclared ingredient in sexual-enhancement supplements. Because the analog itself has not been formally tested, it is best understood through the well-e…

bindsPDE5 enzyme

1 sourceVasodilation

N-Isopropyl Tadalafil pde5

N-Isopropyl Tadalafil is a designer analog of tadalafil, the long-acting PDE5 inhibitor sold as Cialis, differing only by a small change to one part of the molecule. Like its parent, it is presumed to relax blood vessels and enhance erections, and it has been identified as an undeclared ingredient hidden inside sexual-performance supplements. Since the analog has never been formally tested, its profile is inferred…

bindsPDE5 enzyme

1 sourceVasodilation

N163-166 (MOD6) peptide

N163-166 (MOD6) is an orally active peptide engineered to switch the body's own testosterone production back on at its source. It targets VDAC1, a mitochondrial gatekeeper that governs the rate-limiting step of steroid synthesis, prompting the Leydig cells of the testes to make more testosterone rather than supplying an outside hormone. In male rats, VDAC1-derived oral peptides raised circulating testosterone spec…

bindsVDAC1 / 14-3-3 epsilon interaction

1 sourceTestosterone

Y-134 serm

Y-134 is a research-stage selective estrogen receptor modulator (SERM) engineered by fine-tuning the well-known drug raloxifene. Beyond the classic SERM profile of blocking estrogen in breast tissue while supporting bone, Y-134 carries a striking bonus: it switches on the aryl hydrocarbon receptor (AhR) and drives even hard-to-treat triple-negative breast cancer cells into programmed cell death, an effect its pare…

bindsEstrogen receptor alpha (breast)

1 sourceEstrogen receptor signaling

1,3-DMAA stimulant

1,3-DMAA (1,3-dimethylamylamine, methylhexanamine) is a potent aliphatic amine stimulant that defined the golden era of hardcore pre-workouts, prized for driving energy, appetite suppression, and razor focus. Originally patented in the 1940s as a nasal decongestant, it delivers an amphetamine-adjacent lift through indirect adrenergic stimulation and a distinctive vasoconstrictive edge. Its reputation as one of the…

bindsNorepinephrine / dopamine release

1 sourceNorepinephrine

1,4-DMAA stimulant

1,4-DMAA (1,4-dimethylamylamine) is an experimental aliphatic amine stimulant that emerged as a next-generation successor to the banned 1,3-DMAA, marketed for the same hard-hitting pre-workout energy and focus. As a positional isomer of the classic DMAA molecule, it gives formulators a structurally distinct route to intense adrenergic stimulation. It remains a rare, sought-after ingredient in a handful of undergro…

bindsNorepinephrine / dopamine release

1 sourceNorepinephrine

Reference only· 20

Guanfacine adhd

Guanfacine is a non-stimulant ADHD medication and a selective alpha-2A adrenergic receptor agonist, sold as extended-release Intuniv for ADHD and immediate-release Tenex for high blood pressure. It has no dopaminergic reward action and no abuse potential, but it lowers blood pressure and heart rate and must never be stopped abruptly because of rebound hypertension.

bindsAlpha-2A adrenergic receptor

referenceNorepinephrine

Methamphetamine adhd

Methamphetamine is a potent central nervous system stimulant of the substituted amphetamine class. Although it has a limited approved medical role in treating attention-deficit hyperactivity disorder and obesity, it is far better known as an illicitly manufactured drug of abuse, sold in crystalline form and taken for its intense euphoria and stimulation. Methamphetamine raises levels of the neurotransmitters dopam…

bindsDopamine transporter (DAT)

referenceDopamine

RAD-140 + YK-11 blend

RAD-140 (Testolone) plus YK-11 is a popular bodybuilding stack that pairs two selective androgen receptor modulators (SARMs) sought for rapid gains in muscle mass and strength [1]. RAD-140 is a potent nonsteroidal androgen receptor agonist designed to drive muscle growth with fewer of the prostate and hormonal effects of testosterone, while YK-11 is a steroidal SARM marketed as a myostatin-modulating muscle-builde…

bindsAndrogen receptor (RAD-140)EC50 ~0.1 nM

referenceMuscle Growth

(2R,6R)-Hydroxynorketamine antidepressant

(2R,6R)-Hydroxynorketamine is a downstream metabolite of ketamine, and it is the compound at the centre of the most interesting open question in rapid-acting antidepressant research: whether the mood effect can be separated from the dissociation. In mice, a single dose produces the same antidepressant-like changes as ketamine itself [1], yet at the concentrations that produce them it does not measurably block the…

bindsAMPA receptor

referenceMood

1-MNA supplement

1-Methylnicotinamide (1-MNA) is an endogenous metabolite of nicotinamide produced by the enzyme nicotinamide N-methyltransferase (NNMT), and it sits within the nicotinamide and NAD+ salvage pathway. Long regarded as a biologically inert excretory product, it is now recognised as a vasoprotective, anti-thrombotic and anti-inflammatory agent that stimulates endothelial release of prostacyclin (PGI2) and nitric oxide…

bindsEndothelial prostacyclin (PGI2)primary vasoprotective mechanism

referenceendothelium

1,3-Butanediol depressant

1,3-Butanediol is an alcohol-like compound the body metabolizes into beta-hydroxybutyrate, a ketone body and, more prominently, into a beta-hydroxybutyrate ketone, giving it a slow, alcohol-like depressant effect. It's used industrially and as a food-grade solvent, and it's sometimes taken in place of GHB-family drugs. Its slow onset makes dose stacking and overshoot a serious risk.

bindsGABA system (via metabolites)

referenceGABA

17α-Allyl-19-nortestosterone hormone

A synthetic progestin and the major active metabolite of the oral progestogen allylestrenol. It is structurally related to both nandrolone and allyltestosterone but was never marketed as a standalone drug.

bindsProgesterone receptor

referenceProgesterone receptor activity

1B-LSD lysergamide

1B-LSD (1-butyryl-LSD) is a semisynthetic lysergamide bearing a four-carbon butyryl group on the indole nitrogen of lysergic acid diethylamide, distributed as a research chemical. Pharmacological and biotransformation studies of 1-acyl-substituted LSD derivatives indicate that N1-acylation sharply lowers direct affinity and efficacy at 5-HT2A and related serotonin receptors, yet these compounds still evoke the hea…

binds5-HT2A receptor

referenceSerotonin

1cP-AL-LAD lysergamide

1cP-AL-LAD is a doubly modified lysergamide carrying a cyclopropanecarbonyl group on the indole nitrogen of AL-LAD (6-allyl-6-nor-LSD), and it was first formally identified in seized blotter products in Japan. By analogy with other N1-acyl lysergamides it is presumed to act as a prodrug that is cleaved in the body to AL-LAD, a colorful 5-HT2A receptor agonist generally described as comparatively short and gentle.…

binds5-HT2A receptor

referenceSerotonin

all information here is purely educational and research-oriented only. this is not medical advice in any capacity. nothing here is written by a doctor, medical professional, or scientist in any capacity; purely by an independent researcher studying neuroscience. nobody is liable for misuse of these chemicals or injury done except for the user themselves. all information is purely here for safety reasons. links to websites may be affiliate links. please do note. using the outlets + codes here helps keep this free, additionally giving you a discount. thank you