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1B-LSD (1-butyryl-LSD) is a semisynthetic lysergamide bearing a four-carbon butyryl group on the indole nitrogen of lysergic acid diethylamide, distributed as a research chemical. Pharmacological and biotransformation studies of 1-acyl-substituted LSD derivatives indicate that N1-acylation sharply lowers direct affinity and efficacy at 5-HT2A and related serotonin receptors, yet these compounds still evoke the head-twitch response in mice because they are rapidly deacylated in vivo to LSD; this supports classification of 1B-LSD as a prodrug. Once cleaved, the liberated LSD produces the characteristic serotonergic psychedelic state through 5-HT2A receptor agonism. Analytical and in silico toxicological work has since characterized its mass-spectral fingerprint, serum deacylation, and predicted organ-toxicity profile alongside related N1-acyl lysergamides.
- LSD-like headspace
- Long duration
- Classic visual and mood shifts
- Butyryl prodrug hydrolyzed to LSD
- Anxiety in the wrong setting
- Vasoconstriction
- Insomnia after use
Mechanism
The active molecule works chiefly as a partial at the receptor, the driver of the psychedelic state, with additional activity at 5-HT2C, , and receptors. The 1-butyryl group is thought to be removed after dosing to release LSD, so 1B-LSD is essentially a carrier form of LSD. Whether it is fully or only partly converted is not precisely known, so reported potency is a little lower and more variable than plain LSD.
receptor fingerprint
receptorpartial agonist (via LSD)
5-HT2C receptoragonist
receptorpartial agonist
Safetyrisks and cautions, not medical advice
Because conversion is not perfectly characterized, potency can be uncertain and a bit lower than LSD; treat it cautiously. Avoid with a personal or family history of psychosis or bipolar disorder, and never combine lysergamides with MAOIs or strongly serotonergic drugs (serotonin toxicity), or with lithium or tramadol (seizure reports). Not medical advice.
Subjective profileweighing the evidence above
A roundabout way of taking LSD, and the roundabout part is the problem; conversion is not properly characterized, so potency is a guess rather than a number. Nothing here improves on plain LSD except legal status, and every lysergamide caution still applies in full.
Resources
This entry is here for reference.
Research
- 2017first citedCrystal Structure of an LSD-Bound Human Serotonin Receptor.
- 2026most recentThe toxicity of psychedelic LSD derivatives: 1-acetyl-LSD (ALD-52), 1-propionyl-LSD (1P-LSD), 1…
- 1.Pharmacological and biotransformation studies of 1-acyl-substituted derivatives of d-lysergic acid diethylamide (LSD)
- 2.Return of the lysergamides. Part V: Analytical and behavioural characterization of 1-butanoyl-d-lysergic acid diethylamide (1B-LSD)
- 3.In vitro metabolic fate of nine LSD-based new psychoactive substances and their analytical detectability in different urinary screening procedures.
- 4.The toxicity of psychedelic LSD derivatives: 1-acetyl-LSD (ALD-52), 1-propionyl-LSD (1P-LSD), 1-butyryl-LSD (1B-LSD), 1-valeryl-LSD (1V-LSD) and 1-cyclopropylmethanoyl-LSD (1cP-LSD)-prediction of toxicological parameters relevant to clinical and forensic toxicology using multi-in silico approach.
- 5.A highly sensitive UHPLC-MS/MS method for determining 15 designer LSD analogs in biological samples with application to stability studies.
- 6.Forensic Aspects of Designer LSD Analogs Identification by GC-MS (EI) and UV Spectroscopy.
- 7.Comparative stability assessment of novel LSD analogs in dry blood spots and blood using UHPLC-MS/MS: implications for forensic applications.
- 8.Crystal Structure of an LSD-Bound Human Serotonin Receptor.
- 9.Structure of a Hallucinogen-Activated Gq-Coupled 5-HT2A Serotonin Receptor.
9 listed here; entry last updated August 2026
Reviews
My notesprivate to this device
FAQ
How is 1B-LSD different from LSD?
It carries an extra butyryl group that is thought to fall off in the body to give LSD; the experience is expected to be very LSD-like, perhaps slightly less potent.
Is it legal?
Legal status varies widely by country and changes often; check your local laws.
Can I combine it with cannabis or stimulants?
Combinations can amplify anxiety and cardiovascular strain; be cautious. This is not medical advice.
Adverse effects
- Anxiety in the wrong setting
- Vasoconstriction
- Insomnia after use
Notes and cautions
- Slightly variable potency