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1V-LSD (1-valeroyl-LSD), nicknamed "Valerie," is an N1-acylated lysergamide that can be regarded as a higher homolog of ALD-52, 1P-LSD, and 1B-LSD, marketed as a research chemical. In the mouse head-twitch response it acts as a dose-dependent psychedelic with a median effective dose of about 373 nmol/kg, roughly one third the potency of LSD, and like related N1-acyl lysergamides it is believed to be hydrolyzed in vivo to LSD, functioning as a prodrug that engages the 5-HT2A receptor. It has been characterized by extensive mass spectrometry, chromatography, and spectroscopy, and has been identified in seized blotter products in Japan. In silico toxicology has additionally flagged the strongest predicted hERG channel inhibition of its series, suggesting comparatively higher theoretical proarrhythmic potential.
- Very LSD-like experience
- Long duration
- Reliable visual and cognitive character
- Valeryl LSD prodrug, one-third LSD potency
- Anxiety in the wrong setting
- Vasoconstriction
- Insomnia after use
Mechanism
The active molecule works chiefly as a partial at the receptor, the main driver of the psychedelic state, with further activity at 5-HT2C, , and receptors. The 1-valeryl group is thought to be cleaved after dosing to release LSD, so 1V-LSD is essentially a carrier form of LSD. It is generally reported as close to LSD in potency, consistent with efficient conversion.
receptor fingerprint
receptorpartial agonist (via LSD)
5-HT2C receptoragonist
receptorpartial agonist
Safetyrisks and cautions, not medical advice
It is a popular LSD prodrug and generally reported as near LSD in strength, but it remains a research chemical without formal safety data. Avoid with a personal or family history of psychosis or bipolar disorder, and never combine lysergamides with MAOIs or strongly serotonergic drugs (serotonin toxicity), or with lithium or tramadol (seizure reports). Not medical advice.
Subjective profileweighing the evidence above
Functionally a delivery form of LSD, which is both the appeal and the problem: the experience is well described but there is no formal safety data on the molecule itself. Not a beginner's psychedelic, and it stays off the table with a psychosis or bipolar history, and with MAOIs, lithium or tramadol.
Resources
This entry is here for reference.
Research
- 2017first citedCrystal Structure of an LSD-Bound Human Serotonin Receptor.
- 2026most recentThe toxicity of psychedelic LSD derivatives: 1-acetyl-LSD (ALD-52), 1-propionyl-LSD (1P-LSD), 1…
- 1.The toxicity of psychedelic LSD derivatives: 1-acetyl-LSD (ALD-52), 1-propionyl-LSD (1P-LSD), 1-butyryl-LSD (1B-LSD), 1-valeryl-LSD (1V-LSD) and 1-cyclopropylmethanoyl-LSD (1cP-LSD)-prediction of toxicological parameters relevant to clinical and forensic toxicology using multi-in silico approach.
- 2.Return of the lysergamides. Part VII: Analytical and behavioural characterization of 1-valeroyl-d-lysergic acid diethylamide (1V-LSD).
- 3.Identification of LSD analogs, 1cP-AL-LAD, 1cP-MIPLA, 1V-LSD and LSZ in sheet products.
- 4.A highly sensitive UHPLC-MS/MS method for determining 15 designer LSD analogs in biological samples with application to stability studies.
- 5.Forensic Aspects of Designer LSD Analogs Identification by GC-MS (EI) and UV Spectroscopy.
- 6.Comparative stability assessment of novel LSD analogs in dry blood spots and blood using UHPLC-MS/MS: implications for forensic applications.
- 7.Pharmacological and biotransformation studies of 1-acyl-substituted derivatives of d-lysergic acid diethylamide (LSD).
- 8.Crystal Structure of an LSD-Bound Human Serotonin Receptor.
- 9.Structure of a Hallucinogen-Activated Gq-Coupled 5-HT2A Serotonin Receptor.
9 listed here; entry last updated August 2026
Reviews
My notesprivate to this device
FAQ
Why is it called Valerie?
It is a playful nickname derived from the valeryl group; chemically it is 1-valeryl-LSD.
Is it as strong as LSD?
It is thought to convert to LSD in the body and is generally reported as close in potency and character.
Can I redose to extend it?
Fast tolerance makes redosing give diminishing returns and can worsen anxiety and sleeplessness; be cautious. This is not medical advice.
Adverse effects
- Anxiety in the wrong setting
- Vasoconstriction
- Insomnia after use
Notes and cautions
- No formal safety data