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AL-LAD (6-allyl-6-nor-LSD) is a lysergamide psychedelic closely related to LSD, differing by replacement of the N6 methyl group with an allyl group. Like other serotonergic hallucinogens it acts primarily through agonism at the 5-HT2A receptor, and in the mouse head-twitch response assay it produces the characteristic inverted U-shaped dose-response curve, proving only slightly less potent than LSD itself. Users describe strongly visual, colorful effects with a duration comparable to LSD but often somewhat shorter and milder in strength and comedown. Analytical and metabolic studies have detailed its structure, biotransformation, and its acylated prodrug forms such as 1P-AL-LAD and 1cP-AL-LAD, which are hydrolyzed to AL-LAD in the body. A published case of fatal ventricular dysrhythmia associated with its use indicates that, despite its reputation as a gentler LSD analogue, it is not without cardiovascular risk.
- Strong, colorful visuals
- Often shorter than LSD
- Comparatively gentle headspace
- 5-HT2A agonist lysergamide near LSD in potency
- Anxiety possible
- Vasoconstriction
- Insomnia after use
Mechanism
AL-LAD works chiefly as an at the receptor, the receptor most tied to the classic psychedelic state, with secondary activity at other serotonin receptors such as 5-HT2C and . Replacing LSD's N6 methyl with an allyl group modestly changes potency and duration while keeping the core lysergamide character. The result is a strongly visual experience with a somewhat lighter headspace than LSD for many users.
receptor fingerprint
receptoragonist
5-HT2C receptoragonist
receptoragonist
Safetyrisks and cautions, not medical advice
AL-LAD is physiologically LSD-like and generally regarded as gentle, but it is still a genuine psychedelic and lacks formal safety data. Avoid with a personal or family history of psychosis or bipolar disorder, and never combine lysergamides with MAOIs or strongly serotonergic drugs (serotonin toxicity), or with lithium or tramadol (seizure reports). Not medical advice.
Subjective profileweighing the evidence above
Gentler than LSD in most respects, but not a soft version of it: a fatal ventricular dysrhythmia has been reported with its use, and formal safety data does not exist. Give it exactly the respect LSD gets, and keep it well away from MAOIs, lithium and tramadol.
Resources
This entry is here for reference.
Research
- 2017first citedReturn of the lysergamides. Part II: Analytical and behavioural characterization of N(6) -allyl…
- 2025most recentIdentification of two lysergic acid diethylamide analogs, 1-(3-(trimethylsilyl) propionyl) lyse…
- 1.Return of the lysergamides. Part II: Analytical and behavioural characterization of N(6) -allyl-6-norlysergic acid diethylamide (AL-LAD) and (2'S,4'S)-lysergic acid 2,4-dimethylazetidide (LSZ).
- 2.In vitro metabolic fate of nine LSD-based new psychoactive substances and their analytical detectability in different urinary screening procedures.
- 3.Analytical profile, in vitro metabolism and behavioral properties of the lysergamide 1P-AL-LAD.
- 4.A letter reporting a case of fatal ventricular dysrhythmia associated with the LSD analog AL-LAD.
- 5.Genie in a blotter: A comparative study of LSD and LSD analogues' effects and user profile.
- 6.Analytical profile of the lysergamide 1cP-AL-LAD and detection of impurities.
- 7.Forensic Aspects of Designer LSD Analogs Identification by GC-MS (EI) and UV Spectroscopy.
- 8.Identification of two lysergic acid diethylamide analogs, 1-(3-(trimethylsilyl) propionyl) lysergic acid diethylamide (1S-LSD) and 1-(2-thienoyl)-6-allyl-nor-d-lysergic acid diethylamide (1T-AL-LAD), in paper sheet products distributed on the internet.
8 listed here; entry last updated August 2026
Reviews
My notesprivate to this device
FAQ
How does AL-LAD compare to LSD?
Many describe it as very LSD-like but a touch lighter, more visual, and somewhat shorter in duration.
Is it a prodrug?
No; unlike the 1-acyl compounds, AL-LAD is itself the active lysergamide.
Can I mix it with cannabis?
Cannabis can intensify and destabilize a psychedelic; be cautious. This is not medical advice.
Limitations of the evidence
- Limited safety data
Adverse effects
- Anxiety possible
- Vasoconstriction
- Insomnia after use