Pentalgin Neo is a three ingredient Russian analgesic tablet of paracetamol 325 mg, naproxen sodium 220 mg and caffeine 50 mg, used for headache, migraine, dental, musculoskeletal and period pain.
- Three painkillers working together in one Russian tablet
- Paracetamol and naproxen hit different parts of the same pain
- Caffeine measurably lifts the analgesic pair
- Covers headache, migraine, dental and period pain
- Same logic as combination migraine tablets sold everywhere
- PubMed indexes zero records for 'Pentalgin Neo' in any field; there is no indexed pharmacology, no indexed trial and no indexed safety literature for this specific product.
- It is a Russian-market line extension of the Pentalgin brand; its composition differs from classic Pentalgin and must be taken from the manufacturer's registered summary of product characteristics, not from literature.
- No regulatory authority outside the Russian Federation and neighbouring CIS states has evaluated it.
Mechanism
Paracetamol works centrally and naproxen inhibits cyclooxygenase in inflamed tissue, so the two cover different components of the same pain. Caffeine antagonises receptors, speeds gastric emptying and measurably raises the analgesic effect of the pair without contributing much of its own.
Safetyrisks and cautions, not medical advice
Pentalgin Neo is a fixed combination product in the analgesic class. A full adverse effect profile has not been compiled for this entry yet, so nothing here should be read as evidence that it is well tolerated; the absence is missing work rather than a finding. What is documented is what the compound is and what it is used for.
Subjective profileweighing the evidence above
Unlike the five ingredient original, this combination is defensible. Paracetamol and naproxen act on different parts of the same pain and caffeine measurably lifts the pair, which is the same logic behind the combination migraine tablets sold everywhere. The caveats are ordinary NSAID caveats rather than exotic ones: stomach and kidney risk with regular use, and a headache that reliably returns as the tablet wears off is a sign of medication overuse rather than a reason for the next one.
Where to buy
Suppliers
Vendors carrying Pentalgin Neo, with live product details and codes. Links are affiliate links that support the wiki at no cost to you.
RUPharma🌐
Pentalgin Neo
Reviews
My notesprivate to this device
Notes and cautions
- No indexed safety data exist for this specific formulation.
- Any safety statement must be inherited from the individual active ingredients declared on the registered Russian label and must be attributed to that label, not to a study.
- Because Pentalgin-brand products have historically contained metamizole (agranulocytosis risk) and, in older versions, codeine and phenobarbital, the entry should not imply an established safety profile.