AMT

AMT (alpha-methyltryptamine) is an alpha-methylated tryptamine that combines serotonergic psychedelic activity with stimulant properties, acting at 5-HT1A and 5-HT2A receptors and the serotonin transporter while also possessing monoamine oxidase inhibiting activity. The alpha-methyl group confers metabolic resistance analogous to that seen in amphetamines, contributing to its notably long duration of action. Originally investigated in the mid-twentieth century as an antidepressant and MAOI, it later re-emerged as an internet-era "research chemical" hallucinogen. Preclinical work shows that AMT and its methoxylated relatives raise dopamine and serotonin turnover across multiple brain regions, while user self-reports describe strong hallucinogenic effects accompanied by anxiety, nausea, and a heavy body load. Its long duration, MAOI activity, and documented fatal intoxications mark it as a comparatively high-risk member of the tryptamine class.