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4-HO-MiPT (4-hydroxy-N-methyl-N-isopropyltryptamine; miprocin) is a synthetic tryptamine psychedelic and a close structural relative of psilocin, differing by an isopropyl group on the side chain. Its effects derive mainly from potent, efficacious agonism at the 5-HT2A serotonin receptor, with EC50 values in the low-nanomolar range and additional activity across the 5-HT2 family; in the mouse head-twitch model it is a robust psychedelic whose response can be blunted by serotonin transporter inhibition, illustrating how transporter engagement modulates the tryptamine experience. In rats, closely related 4-substituted tryptamines fully substitute for the discriminative stimulus of DOM, consistent with a classic hallucinogen profile. Users often describe it as comparatively gentle and clear-headed, though set and setting remain important.
- Colorful open- and closed-eye visuals
- Mood lift and euphoria
- Often described as clear-headed
- Manageable duration
- Potent 5-HT2A agonist; clear-headed psilocin cousin
- Raised heart rate and blood pressure
- Nausea
- Body tension or restlessness
- Anxiety at higher exposures
Mechanism
Like other classic psychedelics, 4-HO-MiPT acts primarily as an at the receptor, the receptor most tied to the psychedelic state. As a 4-hydroxylated tryptamine it is a direct analog of psilocin and is presumed to share psilocin's broad activity across several serotonin receptors (including 5-HT2C and ), which shapes the visual and emotional character. It does not damage neurons at typical exposures; the experience is a functional change in serotonergic signaling.
receptor fingerprint
receptoragonist
5-HT2C receptoragonist
receptoragonist
Safetyrisks and cautions, not medical advice
The physical risks resemble those of other serotonergic psychedelics: raised heart rate and blood pressure, nausea, and the possibility of intense anxiety or confusion. It should be avoided by anyone with a personal or family history of psychosis or bipolar disorder, and it is dangerous to combine with MAOIs or other strongly serotonergic drugs because of serotonin toxicity. Because it is a research chemical, purity and true dose are often uncertain. Not medical advice.
Subjective profileweighing the evidence above
One of the better-behaved research-chemical tryptamines: clear-headed, colourful, manageable in length, with no reported deaths, though that partly reflects thin data rather than proven safety. It is still a real psychedelic with cardiovascular load, and purity and true dose are entirely on the buyer.
Resources
No suppliers are provided for compounds like this. This entry is here for reference.
Research
- 2020first citedBis(4-hydroxy-N-isopropyl-N-methyl-tryptammonium) fumarate: a new crystalline form of miprocin.
- 2026most recentSerotonin Transporter Blockade Reduces the Psychedelic-Like Effects of 4-Methoxy-N-methyl-N-iso…
- 1.Serotonin Transporter Blockade Reduces the Psychedelic-Like Effects of 4-Methoxy-N-methyl-N-isopropyltryptamine and Related Analogs.
- 2.Structural insights into tryptamine psychedelics: The role of hydroxyl indole ring site in 5-HT2A receptor activation and psychedelic-like activity.
- 3.Discriminative Stimulus Effects of Substituted Tryptamines in Rats.
- 4.Bis(4-hydroxy-N-isopropyl-N-methyl-tryptammonium) fumarate: a new crystalline form of miprocin.
4 listed here; entry last updated August 2026
Reviews
My notesprivate to this device
FAQ
Is 4-HO-MiPT similar to psilocin?
Structurally yes; it is a close analog of psilocin and is thought to work through the same 5-HT2A serotonin mechanism, though its subjective character differs somewhat.
Is it neurotoxic?
There is no evidence of neurotoxicity at typical exposures, but it is a poorly studied research chemical so long-term data are lacking.
What is the main hidden risk?
Dose uncertainty; as a research chemical the actual strength of a given sample is often unknown, which makes overshooting easy.
Adverse effects
- Raised heart rate and blood pressure
- Nausea
- Body tension or restlessness
- Anxiety at higher exposures