data + articles · 1 listed
newest 1992spec sheet9 rows
5-MeO-DiBF is an obscure benzofuran analogue of the tryptamine 5-MeO-DiPT, in which the indole nitrogen is replaced by oxygen to form a benzofuran ring system. By analogy to its tryptamine parent it is presumed to act as a serotonergic agonist at 5-HT2A receptors and to produce a psychedelic state, though essentially no peer-reviewed pharmacological or toxicological data exist for the compound itself. Its potency, duration and safety profile therefore remain uncharacterized, warranting considerable caution. Reported recreational use suggests a relatively clear-headed psychedelic character, but such accounts are anecdotal and unverified.
- Reported to be relatively mild
- Classic serotonergic psychedelic effects
- Visual and mood changes
- Benzofuran analogue presumed to act as a serotonergic psychedelic
- Raised heart rate and blood pressure
- Nausea
- Anxiety or confusion
Mechanism
5-MeO-DiBF is a benzofuran isostere of 5-MeO-DiPT and is presumed to act, like its tryptamine parent, as an at the receptor that drives the psychedelic effect, with possible activity at common to 5-methoxy compounds. Because it is barely studied, precise receptor affinities are unknown and should not be assumed to be strong. Reports suggest a comparatively mild character, consistent with modest serotonergic potency.
receptor fingerprint
receptoragonist
receptoragonist
Safetyrisks and cautions, not medical advice
Expected risks mirror those of serotonergic psychedelics: raised heart rate and blood pressure, nausea, and the possibility of anxiety or confusion. It should be avoided by anyone with a personal or family history of psychosis or bipolar disorder, and it should not be combined with MAOIs or other strongly serotonergic drugs because of serotonin toxicity. As a rare research chemical its purity and potency are uncertain. Not medical advice.
Subjective profileweighing the evidence above
There is nothing to go on here. No published pharmacology, no toxicology, no measured potency, so every claim about it, including the mild reputation, is anecdote. Taking an uncharacterized psychedelic on inference from a cousin molecule is not a reasonable trade.
Resources
No suppliers are provided for compounds like this. This entry is here for reference.
Research
1 listed here; entry last updated July 2026
Reviews
My notesprivate to this device
FAQ
What makes 5-MeO-DiBF unusual?
Its ring system is a benzofuran rather than the indole found in tryptamines; it is essentially an oxygen-for-nitrogen swap on 5-MeO-DiPT.
How does it work?
It is presumed to share the 5-HT2A serotonin agonism of its tryptamine parent.
Is it well studied?
No; it is a rare research chemical with almost no formal human data.
Limitations of the evidence
- Unknown long-term profile
Adverse effects
- Raised heart rate and blood pressure
- Nausea
- Anxiety or confusion