spec sheet10 rows
5-MeO-DALT (5-methoxy-N,N-diallyltryptamine) is a synthetic tryptamine bearing two allyl groups and a 5-methoxy substituent, first prepared by Alexander Shulgin. In vitro receptor screens show it engages a broad array of targets, with relatively high affinity at serotonin 5-HT1A and 5-HT2B receptors and comparatively weaker affinity at 5-HT2A, alongside interactions at sigma sites, alpha-adrenergic and histamine receptors and the serotonin transporter. It induces the head-twitch response in rodents, a 5-HT2A-mediated behavioral proxy for hallucinogenic activity, and substitutes for the prototypical hallucinogen DOM in drug-discrimination studies. The compound is associated with a rapid, energetic and comparatively short experience; case reports document acute intoxications including transient loss of consciousness, delirium and rhabdomyolysis.
- Quick onset
- Energetic, stimulating character
- Shorter duration than many psychedelics
- Broad serotonergic binding with stimulating tryptamine character
- Anxiety at higher exposures
- Nausea
Mechanism
5-MeO-DALT is a 5-methoxy tryptamine and is presumed to act as an at the receptor, the usual driver of psychedelic effects, with likely contributions from other serotonin receptors such as that are common to 5-methoxy tryptamines. Its exact affinity profile in humans is not well established, so its serotonergic activity is described conservatively. The stimulating, restless quality many users report fits a broad serotonergic action rather than a single clean target.
receptor fingerprint
receptoragonist
receptoragonist
Safetyrisks and cautions, not medical advice
Common effects include a racing heart, jaw tension, restlessness, and the possibility of anxiety or confusion, especially at higher exposures. It should be avoided by anyone with a personal or family history of psychosis or bipolar disorder, and it must not be combined with MAOIs or other strongly serotonergic drugs because of serotonin toxicity risk. It is a research chemical of uncertain purity and potency. Not medical advice.
Subjective profileweighing the evidence above
A fair pick if what you actually want is a short, energetic psychedelic rather than a deep one, since the brief duration is its real selling point. Higher doses mostly buy anxiety, jaw tension and nausea, so it rewards restraint more than most.
Resources
No suppliers are provided for compounds like this. This entry is here for reference.
Research
- 2016first citedReceptor binding profiles and quantitative structure-affinity relationships of some 5-substitut…
- 2025most recentMetabolic profiling of 5-Methoxy-N,N-diallyltryptamine in human liver microsomes and zebrafish…
- 1.Toxicology and Analysis of Psychoactive Tryptamines
- 2.Receptor binding profiles and behavioral pharmacology of ring-substituted N,N-diallyltryptamine analogs
- 3.Receptor binding profiles and quantitative structure-affinity relationships of some 5-substituted-N,N-diallyltryptamines.
- 4.Setup of a Serotonin 2A Receptor (5-HT2AR) Bioassay: Demonstration of Its Applicability To Functionally Characterize Hallucinogenic New Psychoactive Substances and an Explanation Why 5-HT2AR Bioassays Are Not Suited for Universal Activity-Based Screening of Biofluids for New Psychoactive Substances.
- 5.Locomotor and discriminative stimulus effects of four novel hallucinogens in rodents.
- 6.Loss of Consciousness and Visual Hallucinations Related to 5-MeO-DALT Intake, a Case Report Confirmed by Toxicological Analyses.
- 7.5-MeO-DALT; a novel designer drug on the market causing acute delirium and rhabdomyolysis.
- 8.Metabolic profiling of 5-Methoxy-N,N-diallyltryptamine in human liver microsomes and zebrafish using LC-Orbitrap MS.
- 9.Investigating the ability of the microbial model Cunninghamella elegans for the metabolism of synthetic tryptamines.
- 10.Metabolism of the tryptamine-derived new psychoactive substances 5-MeO-2-Me-DALT, 5-MeO-2-Me-ALCHT, and 5-MeO-2-Me-DIPT and their detectability in urine studied by GC-MS, LC-MS(n) , and LC-HR-MS/MS.
10 listed here; entry last updated August 2026
Reviews
My notesprivate to this device
FAQ
Is 5-MeO-DALT a long trip?
No; it is known for a comparatively short and fast experience relative to many other psychedelics.
How does it work?
It is presumed to act through serotonin receptors, chiefly 5-HT2A, like other tryptamine psychedelics.
Can I mix it with an antidepressant or MAOI?
Combining it with MAOIs or strongly serotonergic drugs is dangerous because of serotonin toxicity risk.
Adverse effects
- Anxiety at higher exposures
- Nausea
Notes and cautions
- Racing heart
- Jaw tension and restlessness