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newest 2025spec sheet10 rows
4-HO-MPT (4-hydroxy-N-methyl-N-propyltryptamine; meprocin) is an obscure synthetic tryptamine and a 4-hydroxylated analog of psilocin carrying a methyl and a propyl group on the side chain. It is presumed to act as a 5-HT2A serotonin receptor agonist like its better-characterized relatives, producing a classic psychedelic state, though no dedicated receptor or clinical pharmacology has been published. The available research is limited to forensic metabolism: incubation with human hepatocytes identified phase I N-oxidation and N-demethylation together with phase II glucuronidation and sulfation, and 4-OH-MPT-N-oxide and 4-hydroxy-N-propyltryptamine were proposed as biomarkers of consumption. Given the scarcity of formal data it should be treated cautiously.
- Classic tryptamine visuals
- Mood changes
- Altered thought and perception
- Psilocin-type tryptamine with identified intake biomarkers
- Raised heart rate and blood pressure
- Nausea
- Anxiety or confusion
Mechanism
4-HO-MPT is a 4-hydroxy tryptamine closely related to psilocin and to 4-HO-MiPT, and it is presumed to share their mechanism: agonism at the receptor as the core driver of the psychedelic effect, with likely activity at other serotonin receptors such as 5-HT2C and . Because it has not been well characterized, precise receptor affinities are not established and should not be assumed to be strong.
receptor fingerprint
receptoragonist
5-HT2C receptoragonist
Safetyrisks and cautions, not medical advice
As with other serotonergic psychedelics, expect raised heart rate and blood pressure, possible nausea, and the risk of intense anxiety or confusion. It should be avoided by anyone with a personal or family history of psychosis or bipolar disorder, and combining it with MAOIs or other strongly serotonergic drugs risks serotonin toxicity. This is a very poorly studied compound with unknown purity and potency in circulation. Not medical advice.
Subjective profileweighing the evidence above
Nothing here is actually characterized. The pharmacology is assumed from psilocin and the only real research is forensic metabolism work, so potency and purity are both guesswork. No reason to take this over psilocybin, which is studied properly.
Resources
No suppliers are provided for compounds like this. This entry is here for reference.
Research
- 2005first citedSAR of psilocybin analogs: discovery of a selective 5-HT 2C agonist
- 2025most recentStructural insights into tryptamine psychedelics: The role of hydroxyl indole ring site in 5-HT…
- 1.Structural insights into tryptamine psychedelics: The role of hydroxyl indole ring site in 5-HT2A receptor activation and psychedelic-like activity
- 2.SAR of psilocybin analogs: discovery of a selective 5-HT 2C agonist
- 3.Biomarkers of 4-hydroxy-N,N-methylpropyltryptamine (4-OH-MPT) intake identified from human hepatocyte incubations.
3 listed here; entry last updated August 2026
Reviews
My notesprivate to this device
FAQ
How well studied is 4-HO-MPT?
Barely; it is an obscure research chemical with little formal data, so its effects are inferred from close relatives like psilocin and 4-HO-MiPT.
How does it work?
It is presumed to be a 5-HT2A serotonin receptor agonist like other 4-hydroxy tryptamines.
Is the dose predictable?
No; potency and purity of circulating material are uncertain, which is a real hazard.
Limitations of the evidence
- Unknown long-term profile
Adverse effects
- Raised heart rate and blood pressure
- Nausea
- Anxiety or confusion