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4-AcO-MiPT (4-acetoxy-N-methyl-N-isopropyltryptamine) is a synthetic tryptamine, the acetate ester of 4-HO-MiPT and a close analog of psilacetin. It is thought to act as a prodrug for the active 4-HO-MiPT, a full agonist at the 5-HT2A serotonin receptor that mediates its psilocybin-like psychedelic effects. In rodent drug-discrimination studies 4-AcO-MiPT fully substitutes for the classic hallucinogen DOM, supporting a shared serotonergic mechanism, and structure-activity work classes it among psilocybin-like tryptamines whose acetate esters appear to behave as prodrugs. Comparative pharmacology of the MiPT series indicates that concurrent serotonin transporter inhibition can blunt psychedelic-like effects, a property relevant across the broader tryptamine family. Human data specific to 4-AcO-MiPT remain limited.
- Psilocin-like headspace
- Visual and emotional changes
- Moderate duration
- Prodrug of 4-HO-MiPT, a full 5-HT2A agonist
- Nausea and stomach upset
- Anxiety or confusion
- Pupil dilation
Mechanism
4-AcO-MiPT bears an acetyl group at the 4-position that is cleaved in the body to the active 4-HO-MiPT, similar to psilocybin converting to psilocin. The active form agonizes the receptor, the core of the classic psychedelic state, with supporting serotonergic activity at receptors such as and 5-HT2C. The effect is a serotonergic change in perception, mood, and cognition.
receptor fingerprint
receptoragonist (via active metabolite)
receptoragonist
5-HT2C receptoragonist
Safetyrisks and cautions, not medical advice
4-AcO-MiPT is a substituted tryptamine expected to be relatively low in physiological toxicity but psychologically intense and poorly studied, so margins are uncertain. It can cause nausea, anxiety, and disorientation, and should be avoided by anyone with a personal or family history of psychosis or bipolar disorder; combining it with MAOIs or other strongly serotonergic drugs risks serotonin toxicity. Not medical advice.
Subjective profileweighing the evidence above
A well-worn psilocin-style tryptamine that behaves roughly as expected for the family, with a manageable duration. It is still lightly studied, so margins are uncertain, and anyone with a personal or family history of psychosis or bipolar disorder should leave it alone entirely.
Resources
This entry is here for reference.
Research
- 2020first citedDiscriminative Stimulus Effects of Substituted Tryptamines in Rats
- 2026most recentSerotonin Transporter Blockade Reduces the Psychedelic-Like Effects of 4-Methoxy-N-methyl-N-iso…
- 1.Discriminative Stimulus Effects of Substituted Tryptamines in Rats
- 2.Investigation of the Structure-Activity Relationships of Psilocybin Analogues.
- 3.Serotonin Transporter Blockade Reduces the Psychedelic-Like Effects of 4-Methoxy-N-methyl-N-isopropyltryptamine and Related Analogs.
3 listed here; entry last updated August 2026
Reviews
My notesprivate to this device
FAQ
Is 4-AcO-MiPT a prodrug?
Largely yes; it is thought to convert in the body to the active 4-HO-MiPT.
How does it compare to psilocybin?
It is broadly psilocin-like as a substituted tryptamine, though it is much less studied and experiences vary.
What receptor drives it?
Its active form agonizes the 5-HT2A serotonin receptor, the core of classic psychedelics.
Limitations of the evidence
- Limited safety data
Adverse effects
- Nausea and stomach upset
- Anxiety or confusion
- Pupil dilation