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4-AcO-DiPT (4-acetoxy-N,N-diisopropyltryptamine) is a synthetic tryptamine, the acetate ester of 4-HO-DiPT and a member of the diisopropyltryptamine family. It is thought to act as a prodrug that undergoes ester hydrolysis to the active 4-HO-DiPT, a 5-HT2A serotonin receptor agonist; human hepatocyte studies confirm rapid deacetylation followed by glucuronidation and sulfation. The diisopropyl tryptamines are pharmacologically distinctive for producing marked auditory distortion, and controlled work on the parent N,N-diisopropyltryptamine describes a frequency-selective downward shift in perceived pitch alongside hallucinogen-like discriminative effects. Its active metabolite 4-HO-DiPT has attracted interest as a comparatively short-acting psychedelic, and engineered prodrug forms such as RE104 have been advanced in preclinical antidepressant research. Detailed human data on 4-AcO-DiPT itself remain limited.
- Psilocin-like headspace
- Distinctive auditory effects reported
- Visual and emotional changes
- Prodrug of 4-HO-DiPT; noted for auditory pitch shifts
- Nausea and stomach upset
- Auditory distortion that some find unpleasant
- Anxiety or confusion
Mechanism
4-AcO-DiPT bears an acetyl group at the 4-position that is cleaved in the body to give the active 4-HO-DiPT, similar to psilocybin becoming psilocin. The active compound agonizes the receptor, the core of the psychedelic state, with additional serotonergic activity that shapes mood and perception. Diisopropyl tryptamines are associated with unusual auditory effects alongside the usual visual and cognitive changes.
receptor fingerprint
receptoragonist (via active metabolite)
receptoragonist
5-HT2C receptoragonist
Safetyrisks and cautions, not medical advice
4-AcO-DiPT is a substituted tryptamine expected to be relatively low in physiological toxicity but psychologically intense and poorly studied, so its margins are uncertain. It can produce nausea, anxiety, and disorientation, and should be avoided by anyone with a personal or family history of psychosis or bipolar disorder; combining it with MAOIs or other strongly serotonergic drugs risks serotonin toxicity. Not medical advice.
Subjective profileweighing the evidence above
A novelty rather than an upgrade. The auditory pitch shifts are the reason people take it and plenty of them find the effect unsettling rather than interesting; with limited safety data behind it, there is little reason to pick this over the better documented psilocin relatives.
Resources
This entry is here for reference.
Research
- 2013first citedDiscriminative stimulus effects of N,N-diisopropyltryptamine.
- 2026most recentSerotonin Transporter Blockade Reduces the Psychedelic-Like Effects of 4-Methoxy-N-methyl-N-iso…
- 1.Discriminative Stimulus Effects of Substituted Tryptamines in Rats.
- 2.Human Hepatocyte 4-Acetoxy-N,N-Diisopropyltryptamine Metabolite Profiling by Reversed-Phase Liquid Chromatography Coupled with High-Resolution Tandem Mass Spectrometry.
- 3.RE104: Synthesis and Activity of a Novel Serotonergic Psychedelic Prodrug of 4-Hydroxy-N,N-diisopropyltryptamine.
- 4.Serotonin Transporter Blockade Reduces the Psychedelic-Like Effects of 4-Methoxy-N-methyl-N-isopropyltryptamine and Related Analogs.
- 5.Discriminative stimulus effects of N,N-diisopropyltryptamine.
- 6.N,N-Diisopropyltryptamine and diptogenia: proposed mechanisms for a frequency-selective pitch-distorting psychedelic.
6 listed here; entry last updated August 2026
Reviews
My notesprivate to this device
FAQ
Why is the DiPT family unusual?
Diisopropyl tryptamines are known for pronounced auditory distortion, sometimes shifting the pitch of sounds, more than strong visuals.
Is 4-AcO-DiPT a prodrug?
Largely yes; it is thought to convert in the body to the active 4-HO-DiPT.
What receptor does it target?
Its active form agonizes the 5-HT2A serotonin receptor, the shared core of classic psychedelics.
Limitations of the evidence
- Limited safety data
Adverse effects
- Nausea and stomach upset
- Auditory distortion that some find unpleasant
- Anxiety or confusion