4-AcO-MET

4-AcO-MET (4-acetoxy-N-methyl-N-ethyltryptamine) is a synthetic tryptamine, the acetate ester of 4-HO-MET and an asymmetric N-alkyl variant of psilacetin. It is generally considered a prodrug that is hydrolyzed to the active 4-HO-MET, an agonist at the 5-HT2A serotonin receptor producing psilocybin-like effects; structure-activity data indicate that O-acetylation attenuates in vitro 5-HT2A potency while preserving agonist efficacy. Its 4-hydroxy metabolite fully substitutes for the hallucinogen DOM in rodent drug-discrimination testing, and in vitro toxicology has identified hERG channel inhibition and QT prolongation as potential cardiac concerns. The compound and its metabolite have been documented in forensic casework and characterized by crystallographic and analytical methods. Controlled human pharmacology is not well established.