DPT

N,N-Dipropyltryptamine (DPT) is a synthetic tryptamine, the dipropyl homolog of DMT, that has been used both recreationally and, historically, within psychotherapeutic and religious settings. Behavioral pharmacology in rodents indicates that its hallucinogen-like effects are driven mainly by agonism at the serotonin 5-HT2A receptor, with a modulatory contribution from 5-HT1A receptors, and it acts as a substrate at the serotonin and vesicular monoamine transporters. Interestingly, tryptamine hallucinogens such as DPT show less tolerance development than phenethylamine 5-HT2A agonists, and one study reported that DPT can suppress audiogenic seizures in a fragile X syndrome mouse model through a mechanism that appears independent of its serotonergic and sigma-1 activity. Typically smoked, insufflated, or injected, DPT produces an intense and sometimes unpredictable psychedelic state longer in duration than DMT, and fatal outcomes from high-dose nasal use have been documented.