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MET (N-methyl-N-ethyltryptamine) is a synthetic tryptamine closely related to DMT, bearing one methyl and one ethyl substituent on the terminal amine of the side chain. By analogy to other N,N-dialkyltryptamines it is presumed to act mainly as an agonist at serotonin 5-HT2A receptors, and, lacking oral activity from first-pass metabolism, it is typically vaporized or injected to produce a short and intense psychedelic state. Dedicated pharmacological and clinical literature on MET is minimal, and most available information derives from structural analogy to better-characterized tryptamines rather than from direct study of the compound itself.
- DMT-like psychedelic effects
- Relatively short duration
- Rapid onset by smoked route
- Short-acting DMT-like tryptamine acting at 5-HT2A receptors
- Raised heart rate and blood pressure
- Nausea
- Disorienting intensity
Mechanism
MET is presumed to act primarily as an at the receptor, the core psychedelic target, much like its parent DMT, with likely activity at other serotonin receptors. Like short-chain tryptamines it is a substrate for monoamine oxidase, so oral activity is weak and smoked or injected routes act quickly and end relatively soon. Its precise human affinities are not firmly established, so its potency is described conservatively.
receptor fingerprint
receptoragonist
receptoragonist
Safetyrisks and cautions, not medical advice
Effects can include raised heart rate and blood pressure, nausea, and intense, disorienting perceptual changes. It should be avoided by anyone with a personal or family history of psychosis or bipolar disorder, and combining it with MAOIs or other strongly serotonergic drugs risks serotonin toxicity. It is an obscure research chemical of uncertain purity and potency. Not medical advice.
Subjective profileweighing the evidence above
Too obscure to know much about, which is the whole verdict. It has to be vaporized or injected, the dedicated literature is almost nonexistent, and material sold under the name is of uncertain identity and potency. DMT itself is far better characterized if that is the direction.
Resources
No suppliers are provided for compounds like this. This entry is here for reference.
Research
- 1.Discriminative Stimulus Effects of Substituted Tryptamines in Rats
- 2.Effect of ring fluorination on the pharmacology of hallucinogenic tryptamines
2 listed here; entry last updated August 2026
Reviews
My notesprivate to this device
FAQ
How is MET related to DMT?
It swaps one of DMT's methyl groups for an ethyl group and is thought to work through the same 5-HT2A serotonin mechanism.
Does it work if swallowed?
Not reliably on its own, because monoamine oxidase breaks it down quickly; it is usually smoked or injected.
Is it safe with an MAOI?
Combining it with MAOIs or strongly serotonergic drugs is dangerous because of serotonin toxicity risk.
Adverse effects
- Raised heart rate and blood pressure
- Nausea
- Disorienting intensity
Notes and cautions
- Weak or unreliable orally