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5-MeO-DMT (5-methoxy-N,N-dimethyltryptamine), also known as mebufotenin, is a fast-acting serotonergic psychedelic found in the venom of the Sonoran Desert toad and in numerous plants, as well as produced synthetically. It is distinguished among classical psychedelics by pronounced agonism at the 5-HT1A receptor in addition to 5-HT2A, a profile linked to its uniquely intense, short-lived and often ego-dissolving effects. Preclinical work indicates it modulates proteins governing long-term potentiation and dendritic-spine formation in human cerebral organoids, and early-phase clinical trials of a vaporized formulation have reported rapid, sometimes single-day remission in treatment-resistant depression. Owing to its potency and overwhelming acute effects, it carries substantial physiological and psychological risk and is typically used only in carefully controlled settings.
- Extremely intense, ego-dissolving state
- Very short duration when smoked
- Studied for rapid psychological effects
- Ultra-rapid antidepressant action via combined 5-HT1A and 5-HT2A agonism
- Sharp blood pressure spikes
- Vomiting or loss of consciousness
Mechanism
5-MeO-DMT is an at receptors, and compared with most classic psychedelics it shows unusually strong activity at the receptor alongside its agonism; both contribute to its profound, ego-dissolving character. The 5-methoxy group makes it very potent and rapid when smoked or insufflated. It is also a substrate for MAO, which is why combining it with an changes and dangerously prolongs its effects.
receptor fingerprint
receptoragonist
receptoragonist
Safetyrisks and cautions, not medical advice
5-MeO-DMT is extremely potent and psychologically overwhelming, and physical effects can include sharply raised blood pressure, and there have been reports of vomiting, loss of consciousness, and deaths in poorly controlled settings. Combining it with an MAOI (including harmala-containing brews) is especially dangerous and can cause severe serotonin toxicity. It should be avoided by anyone with a personal or family history of psychosis or bipolar disorder or with cardiovascular problems. Not medical advice.
Subjective profileweighing the evidence above
Not a casual psychedelic under any circumstances. It is overwhelming, over in minutes, and the physical side includes sharp blood pressure spikes, vomiting, loss of consciousness and deaths in poorly controlled settings. Never anywhere near an MAOI or a harmala brew.
Resources
No suppliers are provided for compounds like this. This entry is here for reference.
Research
- 2010first citedPsychedelic 5-methoxy-N,N-dimethyltryptamine: metabolism, pharmacokinetics, drug interactions,…
- 2026most recentPsychedelic Therapy: A Primer for Primary Care Clinicians-5-Methoxy-N,N-Dimethyltryptamine.
- 1.5-MeO-DMT: An atypical psychedelic with unique pharmacology, phenomenology & risk?
- 2.Serotonin 1A Receptors Modulate Serotonin 2A Receptor-Mediated Behavioral Effects of 5-Methoxy-N,N-dimethyltryptamine Analogs in Mice
- 3.Psychedelic 5-methoxy-N,N-dimethyltryptamine: metabolism, pharmacokinetics, drug interactions, and pharmacological actions
- 4.A phase 1/2 trial to assess safety and efficacy of a vaporized 5-methoxy-N,N-dimethyltryptamine formulation (GH001) in patients with treatment-resistant depression.
- 5.Psychedelic Therapy: A Primer for Primary Care Clinicians-5-Methoxy-N,N-Dimethyltryptamine.
- 6.Short term changes in the proteome of human cerebral organoids induced by 5-MeO-DMT.
- 7.Modification of 5-methoxy-N,N-dimethyltryptamine-induced hyperactivity by monoamine oxidase A inhibitor harmaline in mice and the underlying serotonergic mechanisms.
- 8.Exploring 5-MeO-DMT as a pharmacological model for deconstructed consciousness.
- 9.Use of Benefit Enhancement Strategies among 5-Methoxy-N,N-Dimethyltryptamine (5-MeO-DMT) Users: Associations with Mystical, Challenging, and Enduring Effects.
9 listed here; entry last updated August 2026
Reviews
My notesprivate to this device
FAQ
How is 5-MeO-DMT different from DMT?
It leans much more heavily on the 5-HT1A receptor and tends to produce a formless, overwhelming state rather than the visual, dreamlike world of DMT.
Why is mixing it with ayahuasca or an MAOI risky?
MAO normally breaks it down; blocking that enzyme dangerously prolongs and intensifies its effects and raises serotonin toxicity risk.
Is it physically dangerous?
It can be; blood pressure spikes, vomiting, and loss of consciousness have been reported, so it demands great caution.
Adverse effects
- Sharp blood pressure spikes
- Vomiting or loss of consciousness
Notes and cautions
- Overwhelming intensity
- High risk if combined with MAOIs