spec sheet10 rows
MiPT (N-methyl-N-isopropyltryptamine) is a synthetic tryptamine structurally related to DMT, bearing methyl and isopropyl groups on the terminal amine and lacking a 4-position substituent. It is presumed to act mainly as a 5-HT2A serotonin receptor agonist, the shared mechanism of classical serotonergic psychedelics. In vitro work has shown that MiPT and related N,N-dialkyltryptamines behave as substrates rather than simple blockers at the serotonin transporter and the vesicular monoamine transporter, allowing intracellular accumulation that may contribute to their neurochemical profile. Its 4-substituted and 5-methoxy analogs, including 4-OH-MiPT, 4-MeO-MiPT, and 5-MeO-MiPT, have been characterized more extensively and display potent 5-HT2A agonism alongside variable transporter activity; MiPT itself is generally described as producing modest visual effects with a clear, introspective character.
- Clear, introspective character
- Modest visuals
- Emotional and cognitive effects
- Serotonergic tryptamine that is also a transporter substrate
- Raised heart rate and blood pressure
- Nausea
- Muscle tension
- Anxiety at higher exposures
Mechanism
MiPT is presumed to act primarily as an at the receptor, the core psychedelic target, with likely activity at other serotonin receptors typical of N-alkyl tryptamines. Unlike its 4-hydroxy relatives it lacks that hydroxyl group, which is thought to contribute to its comparatively low-visual, more cognitive and emotional profile. Its precise human affinities are not firmly established, so its potency is described conservatively.
receptor fingerprint
receptoragonist
receptoragonist
Safetyrisks and cautions, not medical advice
Effects can include raised heart rate and blood pressure, nausea, muscle tension, and the possibility of anxiety at higher exposures. It should be avoided by anyone with a personal or family history of psychosis or bipolar disorder, and it must not be combined with MAOIs or other strongly serotonergic drugs because of serotonin toxicity risk. It is a research chemical of uncertain purity and potency. Not medical advice.
Subjective profileweighing the evidence above
The clear, introspective character is the draw, and the modest visuals suit people who dislike a sensory flood. It is still a research chemical of uncertain purity with a real physical toll of raised heart rate, nausea and muscle tension, off-limits with psychosis or bipolar history and dangerous with MAOIs.
Resources
No suppliers are provided for compounds like this. This entry is here for reference.
Research
- 2007first citedIn vitro screening of psychoactive drugs by [35S]GTPgammaS binding in rat brain membranes.
- 2026most recentSerotonin Transporter Blockade Reduces the Psychedelic-Like Effects of 4-Methoxy-N-methyl-N-iso…
- 1.Receptor interaction profiles of novel psychoactive tryptamines compared with classic hallucinogens.
- 2.Dimethyltryptamine and other hallucinogenic tryptamines exhibit substrate behavior at the serotonin uptake transporter and the vesicle monoamine transporter.
- 3.Serotonin Transporter Blockade Reduces the Psychedelic-Like Effects of 4-Methoxy-N-methyl-N-isopropyltryptamine and Related Analogs.
- 4.Behavioral effects of three synthetic tryptamine derivatives in rodents.
- 5.In vitro screening of psychoactive drugs by [35S]GTPgammaS binding in rat brain membranes.
5 listed here; entry last updated August 2026
Reviews
My notesprivate to this device
FAQ
Is MiPT very visual?
Generally no; it is often described as low on visuals and more introspective and emotional than many tryptamines.
How does it work?
It is presumed to act as a 5-HT2A serotonin receptor agonist like other tryptamine psychedelics.
Can I combine it with an MAOI?
No; combining it with MAOIs or strongly serotonergic drugs is dangerous because of serotonin toxicity risk.
Adverse effects
- Raised heart rate and blood pressure
- Nausea
- Muscle tension
- Anxiety at higher exposures