spec sheet10 rows
5-MeO-DiPT (5-methoxy-N,N-diisopropyltryptamine), popularly called "Foxy," is a synthetic tryptamine combining a 5-methoxy group with two isopropyl side-chain substituents. Microdialysis studies indicate it acts through dual mechanisms, inhibiting the serotonin transporter while simultaneously stimulating 5-HT1A autoreceptors, so that its serotonin-elevating effect is self-limited; it also raises prefrontal dopamine and, like other tryptamine hallucinogens, drives a 5-HT2A-dependent head-twitch response. Users report a strongly physical, sometimes entactogenic experience with notable body load and nausea. Animal studies of repeated adolescent exposure describe lasting changes in monoamine neurotransmission, oxidative DNA damage and impaired learning, underscoring its unpredictable and potentially neurotoxic profile.
- Strong body and tactile effects
- Mood and perceptual changes
- Sometimes described as entactogenic
- Dual serotonin reuptake inhibition with self-limiting 5-HT1A agonism
- Heavy nausea and gut discomfort
- Raised heart rate
Mechanism
5-MeO-DiPT is presumed to act primarily as an at the receptor, the core psychedelic target, with meaningful activity at and likely 5-HT2C that is typical of 5-methoxy tryptamines. This broader serotonergic profile fits the pronounced body effects and mood changes users report. Its precise human affinities are not firmly established, so its potency is described conservatively.
receptor fingerprint
receptoragonist
receptoragonist
5-HT2C receptoragonist
Safetyrisks and cautions, not medical advice
5-MeO-DiPT is well known for a heavy body load: nausea, gut discomfort, muscle tension, and raised heart rate are common. It should be avoided by anyone with a personal or family history of psychosis or bipolar disorder, and it must not be combined with MAOIs or other strongly serotonergic drugs because of serotonin toxicity risk. Purity and potency of research-chemical material are uncertain, and effects can be unpredictable. Not medical advice.
Subjective profileweighing the evidence above
The body load is what most people remember, and it is the main argument against it; nausea, gut discomfort and a raised heart rate for an experience other tryptamines deliver more cleanly. Research-chemical purity is uncertain, and it must never meet an MAOI or another strongly serotonergic drug.
Resources
No suppliers are provided for compounds like this. This entry is here for reference.
Research
- 2015first citedThe hallucinogenic world of tryptamines: an updated review
- 2025most recentEffects of three tryptamines: alpha-methyltryptamine, 5-methoxy-alpha-methyltryptamine, and 5-m…
- 1.The hallucinogenic world of tryptamines: an updated review
- 2.Neurotoxic Effects of 5-MeO-DIPT: A Psychoactive Tryptamine Derivative in Rats
- 3.Dual actions of 5-MeO-DIPT at the serotonin transporter and serotonin 5-HT1A receptor in the mouse striatum and prefrontal cortex.
- 4.Effects of three tryptamines: alpha-methyltryptamine, 5-methoxy-alpha-methyltryptamine, and 5-methoxy-N,N-diisopropyltryptamine on acute toxicity, locomotor activity, and hallucinogenic behavior in mice.
- 5.A systematic study of changes in monoamine neurotransmitters in the rat brain following acute administration of alpha-methyltryptamine (AMT), 5-methoxy-alpha-methyltryptamine (5-MeO-AMT) and 5-methoxy-N,N-diisopropyltryptamine (5-MeO-DiPT).
- 6.Effects of exposure to 5-MeO-DIPT during adolescence on brain neurotransmission and neurotoxicity in adult rats.
- 7.The effect of repeated-intermittent exposure to 5-methoxy-N,N-diisopropyltryptamine (5-MeO-DIPT) during adolescence on learning and memory in adult rats.
- 8.Application of hair analysis to document illegal 5-methoxy-N,N-dissopropyltrptamine (5-MeO-DiPT) use.
- 9.Determination of 5-MeO-DIPT in Human Urine Using Gas Chromatography Coupled with High-Resolution Orbitrap Mass Spectrometry.
- 10.Toxicology and Analysis of Psychoactive Tryptamines.
10 listed here; entry last updated August 2026
Reviews
My notesprivate to this device
FAQ
Why is it called Foxy?
'Foxy' and 'Foxy Methoxy' are the common street names for 5-MeO-DiPT; they refer to the same compound.
Why does it feel so physical?
It is known for a heavy body load with nausea and tension, consistent with its broad serotonergic activity.
Is it safe to mix with antidepressants?
Combining it with MAOIs or strongly serotonergic drugs is dangerous because of serotonin toxicity risk.
Adverse effects
- Heavy nausea and gut discomfort
- Raised heart rate
Notes and cautions
- Muscle tension
- Unpredictable at higher exposures