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5-MeO-MiPT (5-methoxy-N-methyl-N-isopropyltryptamine), nicknamed "Moxy," is a synthetic tryptamine carrying a 5-methoxy group with methyl and isopropyl substituents on the amine. It is presumed to act as a serotonergic hallucinogen at 5-HT2A receptors, and preclinical characterization shows dose-dependent inhibition of sensorimotor and prepulse-inhibition responses together with impaired motor activity and cardiorespiratory changes at high doses. In silico modeling indicates a toxicokinetic profile resembling 5-MeO-DiPT and DMT, with metabolism proceeding largely via O-demethylation and hydroxylation. Users describe pronounced tactile and bodily effects with a moderate visual component; documented human intoxication cases mirror the effects observed in animal models.
- Strong tactile and body effects
- Moderate visuals
- Often described as sensual and energetic
- Serotonergic tryptamine noted for strong tactile and bodily effects
- Raised heart rate and blood pressure
- Muscle tension
- Nausea
- Anxiety at higher exposures
Mechanism
5-MeO-MiPT is presumed to act as an at the receptor that drives the psychedelic effect, with likely activity typical of 5-methoxy tryptamines that contributes to its body and mood character. Its precise human receptor affinities are not firmly established, so its potency is described conservatively. The pronounced tactile quality fits a broad serotonergic action.
receptor fingerprint
receptoragonist
receptoragonist
Safetyrisks and cautions, not medical advice
Common effects include raised heart rate and blood pressure, muscle tension, nausea, and the possibility of anxiety at higher exposures. It should be avoided by anyone with a personal or family history of psychosis or bipolar disorder, and it must not be combined with MAOIs or other strongly serotonergic drugs because of serotonin toxicity risk. As a research chemical its purity and potency are uncertain. Not medical advice.
Subjective profileweighing the evidence above
Moxy has a real following for its tactile, bodily character rather than visuals, and that part is consistent enough to be worth noting. It is still a research chemical with unmapped potency, so treat the raised heart rate, blood pressure and muscle tension as the real cost, and never combine it with serotonergic drugs.
Resources
No suppliers are provided for compounds like this. This entry is here for reference.
Research
- 2016first citedReceptor interaction profiles of novel psychoactive tryptamines compared with classic hallucino…
- 2024most recentPharmaco-toxicological effects of the novel tryptamine hallucinogen 5-MeO-MiPT on motor, sensor…
- 1.Receptor interaction profiles of novel psychoactive tryptamines compared with classic hallucinogens.
- 2.Discriminative Stimulus Effects of Substituted Tryptamines in Rats.
- 3.Pharmaco-toxicological effects of the novel tryptamine hallucinogen 5-MeO-MiPT on motor, sensorimotor, physiological, and cardiorespiratory parameters in mice-from a human poisoning case to the preclinical evidence.
- 4.Proposal of 5-methoxy-N-methyl-N-isopropyltryptamine consumption biomarkers through identification of in vivo metabolites from mice.
- 5.Investigating the ability of the microbial model Cunninghamella elegans for the metabolism of synthetic tryptamines.
- 6.Toxicology and Analysis of Psychoactive Tryptamines.
6 listed here; entry last updated August 2026
Reviews
My notesprivate to this device
FAQ
What is Moxy known for?
Pronounced tactile and body effects with a comparatively modest visual component.
How does it work?
It is presumed to act through serotonin receptors, chiefly 5-HT2A with likely 5-HT1A activity.
Can I combine it with an MAOI?
No; combining it with MAOIs or strongly serotonergic drugs is dangerous because of serotonin toxicity risk.
Adverse effects
- Raised heart rate and blood pressure
- Muscle tension
- Nausea
- Anxiety at higher exposures