spec sheet10 rows
4-HO-DiPT (4-hydroxy-N,N-diisopropyltryptamine) is a synthetic tryptamine and the diisopropyl homolog of psilocin. It acts as an agonist at the 5-HT2A serotonin receptor, and preclinical target profiling indicates broader activity across serotonin receptor subtypes typical of the tryptamine class; in rats it fully substitutes for the discriminative stimulus of the psychedelic DOM. Its distinguishing feature is an unusually rapid onset and notably short duration of action, a property that motivated development of RE104, a glutarate ester prodrug of 4-HO-DiPT that has entered phase 1 human trials as a shorter-duration alternative to psilocybin for depressive disorders. Human pharmacokinetic work shows plasma 4-HO-DiPT appearing within about an hour and correlating with mystical-type and drug-effect measures, and its metabolism proceeds mainly through glucuronidation, sulfation, and N-dealkylation.
- Psilocin-like headspace
- Very fast onset
- Brief overall duration
- Short-acting 5-HT2A psychedelic; basis for RE104 prodrug
- Rapid, potentially overwhelming come-up
- Nausea and stomach upset
- Anxiety or confusion
- Limited safety data
Mechanism
4-HO-DiPT agonizes the receptor, the core of the classic psychedelic state, with additional serotonergic activity at receptors such as and 5-HT2C. Bearing the active 4-hydroxy group directly, it does not require metabolic conversion. Its bulky isopropyl groups are associated with a rapid, comparatively brief experience.
receptor fingerprint
receptoragonist
receptoragonist
5-HT2C receptoragonist
Safetyrisks and cautions, not medical advice
4-HO-DiPT is a substituted tryptamine expected to be relatively low in physiological toxicity but psychologically intense and poorly studied, so margins are uncertain; its fast onset can feel overwhelming. It can cause nausea, anxiety, and disorientation, and should be avoided by anyone with a personal or family history of psychosis or bipolar disorder; combining it with MAOIs or other strongly serotonergic drugs risks serotonin toxicity. Not medical advice.
Subjective profileweighing the evidence above
The short duration is the genuinely interesting part, and it is why the prodrug RE104 is in phase 1 trials; that supervised route is where this molecule actually goes somewhere. On its own it is a poorly studied tryptamine with a come-up fast enough to overwhelm people, and margins nobody has mapped.
Resources
This entry is here for reference.
Research
- 2008first citedLiquid chromatography-atmospheric pressure ionization electrospray mass spectrometry determinat…
- 2025controlled trialSafety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Subcutaneous RE104: A Double-Bl…
- 2026most recentSerotonin Transporter Blockade Reduces the Psychedelic-Like Effects of 4-Methoxy-N-methyl-N-iso…
- 1.RE104: Synthesis and Activity of a Novel Serotonergic Psychedelic Prodrug of 4-Hydroxy-N,N-diisopropyltryptamine.
- 2.Serotonin Transporter Blockade Reduces the Psychedelic-Like Effects of 4-Methoxy-N-methyl-N-isopropyltryptamine and Related Analogs.
- 3.Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Subcutaneous RE104: A Double-Blind, Randomized, Single Ascending Dose Placebo-Controlled Study.
- 4.Discriminative Stimulus Effects of Substituted Tryptamines in Rats.
- 5.Human Hepatocyte 4-Acetoxy-N,N-Diisopropyltryptamine Metabolite Profiling by Reversed-Phase Liquid Chromatography Coupled with High-Resolution Tandem Mass Spectrometry.
- 6.Liquid chromatography-atmospheric pressure ionization electrospray mass spectrometry determination of "hallucinogenic designer drugs" in urine of consumers.
6 listed here; entry last updated August 2026
Reviews
My notesprivate to this device
FAQ
What stands out about 4-HO-DiPT?
It is known for an unusually fast onset and a short duration compared with most psychedelic tryptamines.
Is it a prodrug?
No; it already bears the active 4-hydroxy group, so it does not need conversion.
What is its mechanism?
It agonizes the 5-HT2A serotonin receptor, the shared core of classic psychedelics.
Adverse effects
- Rapid, potentially overwhelming come-up
- Nausea and stomach upset
- Anxiety or confusion
- Limited safety data