data + articles · 3 listed
newest 2025spec sheet10 rows
4-HO-DPT (4-hydroxy-N,N-di-n-propyltryptamine) is a synthetic tryptamine, the di-n-propyl homolog of psilocin. By analogy to related 4-hydroxytryptamines it is presumed to act as an agonist at the 5-HT2A serotonin receptor, producing a psilocin-like psychedelic effect, though it remains obscure and lightly studied. It has been characterized chemically, including by single-crystal X-ray structure of its hydrochloride salt, and appears in analytical toxicology methods as the active metabolite of the ester prodrug 4-MeCO3-DPT. Direct pharmacological and human data are minimal.
- Presumed psilocin-like headspace
- Visual and emotional changes
- Novel research-chemical profile
- Di-n-propyl psilocin analog; presumed 5-HT2A agonist
- Nausea and stomach upset
- Anxiety or confusion
Mechanism
4-HO-DPT is presumed to agonize the receptor, the core of the classic psychedelic state, in common with other 4-hydroxy tryptamines, with likely supporting activity at and 5-HT2C. It bears the active 4-hydroxy group directly, so it does not require metabolic conversion. Because human data are sparse, its exact potency is uncertain and best treated conservatively.
receptor fingerprint
receptoragonist
receptoragonist
Safetyrisks and cautions, not medical advice
As a substituted tryptamine, 4-HO-DPT is expected to be relatively low in physiological toxicity but psychologically intense and very poorly studied, so margins are unknown. It can cause nausea, anxiety, and disorientation, and should be avoided by anyone with a personal or family history of psychosis or bipolar disorder; combining it with MAOIs or other strongly serotonergic drugs risks serotonin toxicity. Not medical advice.
Subjective profileweighing the evidence above
Almost everything said about this one is inference from its chemical relatives rather than measurement, which leaves both potency and safety margin genuinely unknown. Psilocybin or another well-characterized tryptamine covers the same ground with far less guessing.
Resources
This entry is here for reference.
Research
- 2018first citedChemistry and Structure-Activity Relationships of Psychedelics.
- 2025most recentDevelopment and validation of an analytical method for the determination of select 4-position r…
- 1.Chemistry and Structure-Activity Relationships of Psychedelics.
- 2.Development and validation of an analytical method for the determination of select 4-position ring-substituted tryptamines in plasma by liquid chromatography-tandem mass spectrometry.
- 3.The hydrochloride salt of 4-hydroxy-N,N-di-n-propyltryptamine (4-HO-DPT).
3 listed here; entry last updated July 2026
Reviews
My notesprivate to this device
FAQ
What is 4-HO-DPT?
It is the di-n-propyl analog of psilocin, presumed to share its 5-HT2A mechanism, but it is obscure and lightly documented.
Is it a prodrug?
No; it already carries the active 4-hydroxy group, so it does not need conversion.
Is its potency known?
Not reliably; with little human data, potency estimates should be treated cautiously.
Limitations of the evidence
- Largely unknown safety margin
Adverse effects
- Nausea and stomach upset
- Anxiety or confusion