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4-HO-EPT (4-hydroxy-N-ethyl-N-propyltryptamine) is a rare synthetic tryptamine bearing ethyl and propyl groups on the side chain, structurally a 4-hydroxylated psilocin analog sold as a new psychoactive substance. By analogy to related 4-hydroxytryptamines it is presumed to act as a 5-HT2A serotonin receptor agonist, though no dedicated receptor pharmacology has been published. The available literature is confined to forensic metabolism work: incubation with human liver microsomes shows 4-HO-EPT is transformed chiefly by hydroxylation, N-dealkylation, carbonylation, and double-bond formation, and characteristic metabolites have been used to confirm intake in a postmortem case. It remains lightly studied and should be treated cautiously given the absence of formal human pharmacology or toxicology.
- Presumed psilocin-like headspace
- Visual and emotional changes
- Novel research-chemical profile
- Psilocin-like tryptamine with characterized metabolite markers
- Nausea and stomach upset
- Anxiety or confusion
Mechanism
4-HO-EPT is presumed to agonize the receptor, the core of the classic psychedelic state, in common with other 4-hydroxy tryptamines, with likely supporting activity at and 5-HT2C. Carrying the active 4-hydroxy group directly, it does not require metabolic conversion. With sparse human data, its precise potency is uncertain and best treated conservatively.
receptor fingerprint
receptoragonist
receptoragonist
Safetyrisks and cautions, not medical advice
As a substituted tryptamine, 4-HO-EPT is expected to be relatively low in physiological toxicity but psychologically intense and very poorly studied, so margins are unknown. It can cause nausea, anxiety, and disorientation, and should be avoided by anyone with a personal or family history of psychosis or bipolar disorder; combining it with MAOIs or other strongly serotonergic drugs risks serotonin toxicity. Not medical advice.
Subjective profileweighing the evidence above
Not worth it as anything but a curiosity. The only published work is forensic metabolism, including a postmortem case, and its receptor pharmacology has never been measured, while properly characterized psilocin analogs exist. Off the table with any psychosis or bipolar history.
Resources
This entry is here for reference.
Research
- 1.Chemistry and Structure-Activity Relationships of Psychedelics
- 2.Metabolite markers for three synthetic tryptamines N-ethyl-N-propyltryptamine, 4-hydroxy-N-ethyl-N-propyltryptamine, and 5-methoxy-N-ethyl-N-propyltryptamine.
2 listed here; entry last updated July 2026
Reviews
My notesprivate to this device
FAQ
What is 4-HO-EPT?
It is the ethyl-propyl analog of psilocin, presumed to share its 5-HT2A mechanism, but it is rare and lightly studied.
Is it directly active?
Yes; it bears the active 4-hydroxy group, so unlike the acetoxy tryptamines it does not need conversion.
How does it work?
It is presumed to agonize the 5-HT2A serotonin receptor, the core of classic psychedelics.
Adverse effects
- Nausea and stomach upset
- Anxiety or confusion
Notes and cautions
- Largely unknown safety margin