data + articles · 2 listed
newest 2022spec sheet10 rows
5-alpha-Hydroxy-Laxogenin is a spirostanol brassinosteroid, a plant sterol, sold in supplements as a "natural anabolic" or adaptogen. Despite the marketing, solid human evidence that it builds muscle or acts like an anabolic steroid is essentially absent. It is best thought of as a plant-derived compound with claimed but unproven ergogenic effects.
- Marketed as a non-hormonal "natural anabolic"
- Promoted as an adaptogen for training stress
- Plant-derived rather than a synthetic steroid
- No reliable human interaction data
Mechanism
Laxogenin and its hydroxylated derivatives are brassinosteroids, a class of plant steroids structurally reminiscent of animal steroids but not identical to them. Marketing often implies effects on protein synthesis or balance, but there is no well-established human receptor mechanism; brassinosteroids do not act on the human the way anabolic steroids do, and most supportive data come from plant biology or limited preclinical work. Any adaptogenic framing is speculative rather than grounded in defined human pharmacology. In short, its real mechanism in people is not established, so claims should be read cautiously.
receptor fingerprint
Muscle protein synthesis (claimed)purported enhancer
Stress/adaptogen pathways (claimed)purported modulator
Dosingtypical ranges, not medical advice
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Safetyrisks and cautions, not medical advice
Because human data are sparse, both the benefits and the risks of this supplement are poorly defined, and product quality and actual content vary widely in the unregulated supplement market. Anything marketed as "anabolic" should be approached with skepticism, and people with liver concerns or those taking other medications have no reliable interaction data to rely on. Treat bold muscle-building claims as unproven. Not medical advice.
Subjective profileweighing the evidence above
Not worth the money. The natural anabolic claim has no human evidence behind it, there is no established receptor mechanism, and the products carrying it sit in an unregulated market where content varies. Skepticism is the right response to anything sold on an anabolic promise with no data.
Resources
This entry is here for reference.
Research
- 1.Androgenic properties of the dietary supplement 5α-hydroxy-laxogenin
- 2.The power of hyphenated chromatography-Time of flight mass spectrometry for unequivocal identification of spirostanes in bodybuilding dietary supplements
2 listed here; entry last updated July 2026
Reviews
My notesprivate to this device
FAQ
Does 5-alpha-hydroxy-laxogenin build muscle like a steroid?
There is essentially no solid human evidence for that; it is a plant brassinosteroid that does not act on the human androgen receptor the way anabolic steroids do.
Is it an anabolic steroid?
No; it is a plant sterol marketed as a "natural anabolic," which is a marketing framing rather than a demonstrated fact.
Is it safe?
Its safety is poorly defined because human studies are lacking, and supplement products vary a lot in quality and content.
Limitations of the evidence
- Unproven efficacy and largely unknown risks
Adverse effects
- No reliable human interaction data
Notes and cautions
- Variable supplement quality and dosing