spec sheet10 rows
TMA-6 (2,4,6-trimethoxyamphetamine) is another isomer of the trimethoxyamphetamine series, distinguished by its symmetric arrangement of methoxy groups at the 2, 4, and 6 ring positions. It is a serotonergic psychedelic acting through 5-HT2A receptor agonism, reported to be more potent than mescaline and to have a long duration with a comparatively clear-headed, mescaline-like character. Because it is a positional isomer of the controlled parent TMA, analytical chemistry work has focused on reliably distinguishing it from related isomers for forensic and regulatory purposes. It is otherwise only lightly studied, and human pharmacological and safety data are sparse.
- Mescaline-like, often clear-headed character
- More potent than the parent TMA
- Long-lasting experience
- Symmetric 2,4,6-methoxy isomer with clear-headed character
- Nausea and body load
- Stimulant load; raised heart rate and blood pressure
- Anxiety or confusion at higher strength
Mechanism
TMA-6 is a trimethoxy-substituted amphetamine with methoxy groups at the 2, 4, and 6 positions; like other members of the family its psychedelic effects arise from agonism at the receptor, with likely secondary serotonin receptor activity. The alpha-methyl (amphetamine) group slows its breakdown, giving it a long duration. Human affinity and pharmacokinetic figures are limited, so specifics should be treated cautiously.
receptor fingerprint
receptoragonist
5-HT2C receptoragonist (presumed)
Safetyrisks and cautions, not medical advice
TMA-6 is more potent than mescaline and long-lasting, so overshooting the strength or the duration is a real risk, and its amphetamine backbone adds cardiovascular and vasoconstrictive strain. Expect possible nausea, anxiety, and confusion. Combining it with MAOIs or other serotonergic drugs risks serotonin toxicity, and people with heart problems or a psychosis history should avoid it. Not medical advice.
Subjective profileweighing the evidence above
For people who already know the mescaline family and want a long, clear-headed version of it. Potency is higher than mescaline and the duration is long, so clearing the day matters more than usual, and the amphetamine backbone adds real cardiovascular load on top of the nausea.
Resources
This entry is here for reference.
Research
- 1.Discrimination and identification of the six aromatic positional isomers of trimethoxyamphetamine (TMA) by gas chromatography-mass spectrometry (GC-MS).
- 2.The effects of non-medically used psychoactive drugs on monoamine neurotransmission in rat brain.
- 3.Creation and application of psychoactive designer drugs data library using liquid chromatography with photodiode array spectrophotometry detector and gas chromatography-mass spectrometry.
3 listed here; entry last updated August 2026
Reviews
My notesprivate to this device
FAQ
How is TMA-6 different from TMA-2?
The methoxy groups sit at the 2, 4, and 6 positions rather than 2, 4, and 5, which gives it a somewhat different character while remaining a potent psychedelic.
How does it work?
Mainly through agonism at the 5-HT2A serotonin receptor.
How long does it last?
It is long-acting; the amphetamine backbone slows its metabolism, so an experience can span many hours.
Limitations of the evidence
- Limited human safety data
Adverse effects
- Nausea and body load
- Stimulant load; raised heart rate and blood pressure
- Anxiety or confusion at higher strength