spec sheet10 rows
2C-T-7 is a sulfur-containing member of the 2C family of psychedelic phenethylamines, bearing a propylthio group at the 4 position. It acts primarily as a partial agonist at the 5-HT2A serotonin receptor, to which it and related 4-thio compounds bind with nanomolar affinity; in rodents it produces hallucinogen-like behaviors such as the head-twitch response and drug-discrimination cues characteristic of 5-HT2A agonists. Repeated dosing induces tolerance and cross-tolerance with other phenethylamine hallucinogens, and in vitro data indicate interaction with monoamine oxidases. Sometimes marketed as 'Blue Mystic,' it carries a rougher safety reputation than simpler 2C compounds; several deaths, some confirmed by postmortem toxicology, have been linked to it, particularly at high doses or when insufflated.
- Long, visual, introspective psychedelic character
- Classic 5-HT2A phenethylamine profile
- Long-acting partial 5-HT2A agonist with documented fatalities
- Nausea, anxiety, overheating at higher doses
- Very long duration makes redosing risky
Mechanism
2C-T-7 is a 2,5-dimethoxyphenethylamine bearing a thioether (sulfur-linked propyl) group at the 4 position. Its core action is agonism at the receptor, the receptor that drives the classic psychedelic state, with additional activity at 5-HT2C and other serotonin sites. The sulfur substitution lengthens its duration relative to 2C-B, and the thioether group is thought to interact with monoamine oxidase, which is one reason combinations are considered especially risky here.
receptor fingerprint
receptoragonist
5-HT2C receptoragonist
Safetyrisks and cautions, not medical advice
2C-T-7 has a narrower safety record than most 2Cs; fatalities have occurred, particularly with insufflation and with high oral doses, sometimes involving seizures, agitation, and hyperthermia (dangerous overheating). It should never be combined with MAOIs or other strongly serotonergic drugs because of serotonin toxicity, and its slow, long course makes redosing easy to misjudge. People with heart conditions or a personal or family history of psychosis should avoid it. Not medical advice.
Subjective profileweighing the evidence above
One of the few 2Cs with an actual body count. The very long course invites redosing that has killed people, insufflation has been the worst of it, and hyperthermia and seizures are documented. Not worth it when the rest of the family is better understood.
Resources
This entry is here for reference.
Research
- 2003first citedPostmortem identification and quantitation of 2,5-dimethoxy-4-n-propylthiophenethylamine using…
- 2023most recentUse of the head-twitch response to investigate the structure-activity relationships of 4-thio-s…
- 1.Use of the head-twitch response to investigate the structure-activity relationships of 4-thio-substituted 2,5-dimethoxyphenylalkylamines
- 2.Postmortem identification and quantitation of 2,5-dimethoxy-4-n-propylthiophenethylamine using GC-MSD and GC-NPD
- 3.Hallucinogen-like actions of 2,5-dimethoxy-4-(n)-propylthiophenethylamine (2C-T-7) in mice and rats.
- 4.Behavioral and neurochemical pharmacology of six psychoactive substituted phenethylamines: mouse locomotion, rat drug discrimination and in vitro receptor and transporter binding and function.
- 5.Receptor interaction profiles of novel N-2-methoxybenzyl (NBOMe) derivatives of 2,5-dimethoxy-substituted phenethylamines (2C drugs).
- 6.Tolerance and cross-tolerance to head twitch behavior elicited by phenethylamine- and tryptamine-derived hallucinogens in mice.
- 7.Interactions of phenethylamine-derived psychoactive substances of the 2C-series with human monoamine oxidases.
- 8.New trends in the cyber and street market of recreational drugs? The case of 2C-T-7 ('Blue Mystic').
- 9.LC-MS/MS screening method for designer amphetamines, tryptamines, and piperazines in serum.
9 listed here; entry last updated August 2026
Reviews
My notesprivate to this device
FAQ
Is 2C-T-7 dangerous?
It carries more documented risk than simpler 2Cs, with several deaths linked to it, particularly from insufflation and high doses.
How does it work?
Mainly through agonism at the 5-HT2A serotonin receptor, like the rest of the 2C family.
Can it be mixed with antidepressants or MAOIs?
MAOIs are especially dangerous with 2C-T-7; strongly serotonergic drugs raise the risk of serotonin toxicity and should be avoided.
Adverse effects
- Nausea, anxiety, overheating at higher doses
- Very long duration makes redosing risky
Notes and cautions
- Documented deaths, especially when snorted