spec sheet10 rows
2C-T-2 is a sulfur-containing member of the 2C-T subfamily of psychedelic phenethylamines, bearing an ethylthio group at the 4 position of the 2,5-dimethoxyphenethylamine scaffold. Like related 4-thio-substituted phenylalkylamines, it binds with nanomolar affinity to 5-HT2A, 5-HT2B, and 5-HT2C receptors and behaves as a partial agonist at 5-HT2A, the interaction generally held to mediate its psychedelic effects; in mouse head-twitch assays, extension of the 4-alkylthio chain increases potency. In vitro work also shows that 2C-T compounds interact with human monoamine oxidases, consistent with the recognized and potentially serious hazard of combining them with MAO inhibitors. It is characterized by slow onset, long duration, and a pronounced body load.
- Classic 5-HT2A serotonergic psychedelic
- Long, immersive experience
- Distinctive character within the 2C-T subfamily
- Partial 5-HT2A agonist with monoamine oxidase interaction
- Heavy body load with strong nausea
- Marked vasoconstriction
- Serious, potentially fatal MAOI interaction
Mechanism
2C-T-2 is 2,5-dimethoxyphenethylamine with an ethylthio (sulfur-ethyl) group at the 4-position; it acts as an at the receptor, the core psychedelic target, with secondary serotonin receptor activity. The sulfur substituent marks it as part of the 2C-T subfamily, which tends toward slow, long experiences with pronounced physical effects.
receptor fingerprint
receptoragonist
5-HT2C receptoragonist
Safetyrisks and cautions, not medical advice
2C-T-2 has a substantial body load with strong nausea and vasoconstriction, and its slow onset can tempt premature redosing. Most importantly, 2C-T compounds have been associated with severe and even fatal reactions when combined with MAOIs, so that combination must be strictly avoided; the same goes for other strongly serotonergic drugs because of serotonin toxicity. People with cardiovascular problems or a psychosis history should avoid it. Not medical advice.
Subjective profileweighing the evidence above
A poorly studied research chemical whose defining fact is that combining it with an MAOI has caused severe and fatal reactions; that alone puts it outside casual use. Heavy nausea and marked vasoconstriction make it a rough experience even when nothing goes wrong.
Resources
This entry is here for reference.
Research
- 2005first citedScreening for and validated quantification of phenethylamine-type designer drugs and mescaline…
- 2023most recentUse of the head-twitch response to investigate the structure-activity relationships of 4-thio-s…
- 1.Use of the head-twitch response to investigate the structure-activity relationships of 4-thio-substituted 2,5-dimethoxyphenylalkylamines
- 2.Receptor interaction profiles of novel N-2-methoxybenzyl (NBOMe) derivatives of 2,5-dimethoxy-substituted phenethylamines (2C drugs).
- 3.Behavioral and neurochemical pharmacology of six psychoactive substituted phenethylamines: mouse locomotion, rat drug discrimination and in vitro receptor and transporter binding and function.
- 4.Interactions of phenethylamine-derived psychoactive substances of the 2C-series with human monoamine oxidases.
- 5.Screening for and validated quantification of phenethylamine-type designer drugs and mescaline in human blood plasma by gas chromatography/mass spectrometry.
- 6.Tolerance and cross-tolerance to head twitch behavior elicited by phenethylamine- and tryptamine-derived hallucinogens in mice.
6 listed here; entry last updated August 2026
Reviews
My notesprivate to this device
FAQ
How does 2C-T-2 work?
Mainly through agonism at the 5-HT2A serotonin receptor, like the other 2C psychedelics.
What is the most serious interaction?
MAOIs; 2C-T compounds have been linked to severe and even fatal reactions when combined with them, so that pairing must be avoided.
What is the experience like physically?
It tends to have a slow onset, long duration, and a heavy body load with strong nausea.
Adverse effects
- Heavy body load with strong nausea
- Marked vasoconstriction
- Serious, potentially fatal MAOI interaction
Notes and cautions
- Slow onset invites premature redosing