spec sheet10 rows
2C-P is among the most potent and longest-lasting members of the 2C family, carrying a propyl group at the 4-position of the 2,5-dimethoxyphenethylamine ring. It acts mainly through agonism at 5-HT2A serotonin receptors, and receptor-profiling studies place it among the higher-affinity 2C phenethylamines, consistent with the general trend of increasing potency as the 4-alkyl chain is lengthened. Its combination of high potency, slow onset, and very long duration makes accidental overshoot of an intended dose its principal hazard, and it appears in clinical toxicology and European monitoring reports of 2C designer drugs. It also shows measurable monoamine oxidase inhibition in vitro, a property relevant to potential drug interactions.
- Potent 5-HT2A serotonergic psychedelic
- Deep, immersive, long experience
- Strong visual character
- Among the most potent, longest-lasting 2C 5-HT2A agonists
- Strong nausea and vasoconstriction
- Anxiety or difficult experiences
Mechanism
2C-P is 2,5-dimethoxyphenethylamine with a propyl group at the 4-position; it acts as an at the receptor, the core psychedelic target, with secondary serotonin receptor activity. The longer 4-alkyl chain raises both potency and duration compared with most of its 2C siblings.
receptor fingerprint
receptoragonist
5-HT2C receptoragonist
Safetyrisks and cautions, not medical advice
2C-P is potent, slow to come on, and very long-lasting, a combination that leads people to redose too early thinking nothing is happening and then find themselves far too deep for many hours. Higher exposure brings intense nausea, marked vasoconstriction, anxiety, and in some reports vasospasm. Combining it with MAOIs or other serotonergic drugs risks serotonin toxicity, and people with cardiovascular problems or a psychosis history should avoid it. Not medical advice.
Subjective profileweighing the evidence above
Not a first psychedelic. High potency, slow onset and a very long duration combine into one hazard above all others: redosing because nothing seems to be happening, then finding yourself far deeper for far longer than intended. Experienced users with a cleared schedule only.
Resources
This entry is here for reference.
Research
- 2013first cited2C or not 2C: phenethylamine designer drug review.
- 2021most recentNew designer phenethylamines 2C-C and 2C-P have abuse potential and induce neurotoxicity in rod…
- 1.New designer phenethylamines 2C-C and 2C-P have abuse potential and induce neurotoxicity in rodents
- 2.Receptor interaction profiles of novel N-2-methoxybenzyl (NBOMe) derivatives of 2,5-dimethoxy-substituted phenethylamines (2C drugs)
- 3.Interactions of phenethylamine-derived psychoactive substances of the 2C-series with human monoamine oxidases.
- 4.2C or not 2C: phenethylamine designer drug review.
- 5.New phenethylamines in Europe.
5 listed here; entry last updated August 2026
Reviews
My notesprivate to this device
FAQ
Why is 2C-P easy to overshoot?
It comes on slowly and is very potent, so people redose thinking it failed, then find the effects far too strong and long-lasting.
How does it work?
Mainly through agonism at the 5-HT2A serotonin receptor.
What is a key interaction to avoid?
MAOIs and other strongly serotonergic drugs, because of serotonin toxicity risk.
Adverse effects
- Strong nausea and vasoconstriction
- Anxiety or difficult experiences
Notes and cautions
- Slow onset invites premature redosing and overshooting
- Very long duration