DOM

DOM (2,5-dimethoxy-4-methylamphetamine), historically distributed as STP, is a potent, long-acting psychedelic amphetamine of the DOx family carrying a methyl group at the 4 position. It acts chiefly as an agonist at serotonin 5-HT2A receptors, and its potency correlates with 5-HT2 binding affinity, a relationship established in the radioligand studies that helped implicate this receptor as the common site of action for phenylisopropylamine hallucinogens. Synthesized by Alexander Shulgin and later characterized extensively in rodent and primate drug-discrimination work, DOM became a widely used training drug for probing 5-HT2A-mediated interoceptive effects and for screening novel agonists and antagonists. It gained notoriety after high-dose tablets were distributed on the street in 1967, producing prolonged, difficult experiences and a wave of hospital presentations. The compound produces a long psychedelic state with a stimulant edge and pronounced body load.