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Escaline is a psychedelic phenethylamine of the mescaline-analog scaline family, corresponding to mescaline with an ethoxy group replacing the 4-position methoxy. Like its parent it acts principally through agonism at serotonin 5-HT2A receptors, producing a mescaline-like state often described as clear and warm but with substantially greater potency by weight. Systematic head-twitch studies in mice have confirmed that homologation of the 4-alkoxy substituent, from methoxy to ethoxy or propoxy, increases 5-HT2A-mediated potency, mirroring the human potency relationships reported by Shulgin. Structural comparisons within fluorinated analogs further illustrate how modification at this position modulates activity and duration. Escaline remains only lightly studied, and detailed human safety and pharmacokinetic data are lacking.
- Mescaline-like, clear, warm psychedelic character
- More potent than mescaline by weight
- Potency raised by 4-ethoxy homologation of mescaline
- Nausea and body load
Mechanism
Escaline is a 3,5-dimethoxy-4-ethoxy phenethylamine, a direct homolog of mescaline where the 4-methoxy is lengthened to an ethoxy group. Its core action is agonism at the receptor, the receptor that drives the classic psychedelic state, with secondary serotonin (5-HT2C) activity. Lengthening the 4-position alkoxy chain increases 5-HT2A affinity, so escaline is several times more potent than mescaline by weight.
receptor fingerprint
receptoragonist
5-HT2C receptoragonist
Safetyrisks and cautions, not medical advice
Escaline is more potent than mescaline, so dosing errors are easier, and human safety data are limited; nausea and body load are commonly reported. As a serotonergic psychedelic it should not be combined with MAOIs or other strongly serotonergic drugs because of serotonin toxicity. People with heart conditions or a personal or family history of psychosis should avoid it. Not medical advice.
Subjective profileweighing the evidence above
Mescaline's character at a fraction of the weight, which sounds convenient and is actually the risk; the smaller the active dose, the easier the mistake. Human safety data is limited, nausea and body load come standard, and MAOIs, heart conditions or a psychosis history rule it out.
Resources
This entry is here for reference.
Research
- 1.Fluorine in psychedelic phenethylamines.
- 2.Comparison of the behavioral effects of mescaline analogs using the head twitch response in mice.
2 listed here; entry last updated August 2026
Reviews
My notesprivate to this device
FAQ
How is escaline related to mescaline?
It is mescaline with the 4-position methoxy lengthened to an ethoxy group, which makes it several times more potent by weight.
How does it work?
Mainly through agonism at the 5-HT2A serotonin receptor, like other scaline-family psychedelics.
Is it stronger than mescaline?
Yes, by weight, though the character is often described as broadly mescaline-like.
Limitations of the evidence
- Limited human safety data
Adverse effects
- Nausea and body load
Notes and cautions
- Higher potency than mescaline raises dosing-error risk