data + articles · 6 listed
newest 2019spec sheet10 rows
2C-E is one of the more potent and intense members of the 2C family, bearing an ethyl group at the 4-position of the 2,5-dimethoxyphenethylamine scaffold. It acts mainly as a 5-HT2A receptor agonist, with the 2C series showing nanomolar affinity and partial-agonist activity at 5-HT2A and 5-HT2C receptors, and it is noted for deep and sometimes challenging effects, a substantial body load, and a comparatively narrow margin between a moderate and an overwhelming experience. It shows measurable monoamine oxidase inhibition in vitro, which may contribute to interaction risks. It has been implicated in cases of severe intoxication, and clinical toxicology reviews associate high doses of 2C compounds with agitation, seizures, hyperthermia, and an excited-delirium presentation in the most serious cases. The compound and its rigidified 2C-E-FLY analog have been characterized analytically for metabolism and urinary detection.
- Potent 5-HT2A serotonergic psychedelic
- Deep, immersive character
- Strong visual and cognitive effects
- High-efficacy 5-HT2A agonism with pronounced visual intensity
- Strong nausea and body load
- Marked vasoconstriction
- Anxiety or difficult experiences
Mechanism
2C-E is 2,5-dimethoxyphenethylamine with an ethyl group at the 4-position; it acts as an at the receptor, the core psychedelic target, with secondary activity at other serotonin receptors. It is more potent than most of its 2C siblings, which is part of why small differences in exposure produce large differences in intensity.
receptor fingerprint
receptoragonist
5-HT2C receptoragonist
Safetyrisks and cautions, not medical advice
2C-E is potent and intense, and the margin between a manageable and an overwhelming experience is narrow, so misjudging strength readily leads to frightening or physically taxing episodes with strong nausea, vasoconstriction, and anxiety. Combining it with MAOIs or other serotonergic drugs risks serotonin toxicity, and people with cardiovascular problems or a psychosis history should avoid it. Not medical advice.
Subjective profileweighing the evidence above
Among the least forgiving psychedelics in circulation; small differences in dose produce very different experiences, and severe intoxications have been documented. Not a starting point, and off the table entirely with MAOIs, cardiovascular problems or a psychosis history.
Resources
This entry is here for reference.
Research
- 2008first citedLiquid chromatography-atmospheric pressure ionization electrospray mass spectrometry determinat…
- 2019most recentInteractions of phenethylamine-derived psychoactive substances of the 2C-series with human mono…
- 1.2C or not 2C: phenethylamine designer drug review
- 2.Receptor interaction profiles of novel N-2-methoxybenzyl (NBOMe) derivatives of 2,5-dimethoxy-substituted phenethylamines (2C drugs)
- 3.Interactions of phenethylamine-derived psychoactive substances of the 2C-series with human monoamine oxidases.
- 4.Liquid chromatography-atmospheric pressure ionization electrospray mass spectrometry determination of "hallucinogenic designer drugs" in urine of consumers.
- 5.Phenethylamine-derived new psychoactive substances 2C-E-FLY, 2C-EF-FLY, and 2C-T-7-FLY: Investigations on their metabolic fate including isoenzyme activities and their toxicological detectability in urine screenings.
- 6.New phenethylamines in Europe.
6 listed here; entry last updated July 2026
Reviews
My notesprivate to this device
FAQ
Is 2C-E strong?
Yes, it is one of the more potent and intense 2C compounds, with a narrow margin between a moderate and an overwhelming experience.
How does it work?
Mainly through agonism at the 5-HT2A serotonin receptor.
What should not be combined with it?
MAOIs and other strongly serotonergic drugs, because of serotonin toxicity risk.
Adverse effects
- Strong nausea and body load
- Marked vasoconstriction
- Anxiety or difficult experiences
Notes and cautions
- Narrow margin between moderate and overwhelming