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newest 2019spec sheet10 rows
2C-C is a member of the 2C series of psychedelic phenethylamines bearing a chlorine substituent at the 4-position of the 2,5-dimethoxyphenethylamine scaffold. In vitro binding and functional studies show that it acts as a partial agonist at serotonin 5-HT2A and 5-HT2C receptors with nanomolar affinity, the pharmacodynamic basis shared across the family; in rats it produces 5-HT2A-mediated behaviors that are fully blocked by the selective antagonist M100907. Compared with N-benzylated analogs such as 25C-NBOMe it is considerably less potent, consistent with its reputation as one of the gentler and shorter-acting 2C compounds. It shows only modest inhibition of monoamine oxidase in vitro. It is commonly grouped with other 2C designer drugs in analytical and clinical toxicology surveillance.
- Classic 5-HT2A serotonergic psychedelic
- Often described as gentle and relaxing
- Shorter and less stimulating than DOx amphetamines
- Mild 4-chloro 5-HT2A partial agonist
- Nausea and some vasoconstriction
- Anxiety or confusion at higher amounts
Mechanism
2C-C is 2,5-dimethoxyphenethylamine with a chlorine substituent at the 4-position; it acts as an at the receptor, the receptor central to the classic psychedelic state, with secondary activity at 5-HT2C and other serotonin sites. The 2C phenethylamines lack the alpha-methyl group of the amphetamine DOx series, so they tend to be shorter-acting and less stimulating.
receptor fingerprint
receptoragonist
5-HT2C receptoragonist
Safetyrisks and cautions, not medical advice
2C-C is relatively mild for the family, but the usual psychedelic cautions apply: it can cause anxiety or confusion, nausea, and some vasoconstriction, and misjudging strength is easy with any potent 2C compound. It is dangerous to combine with MAOIs or other strongly serotonergic drugs because of serotonin toxicity, and people with cardiovascular problems or a psychosis history should avoid it. Not medical advice.
Subjective profileweighing the evidence above
One of the gentler entry points in the 2C family if you are going to explore the series at all, shorter and less driving than the DOx compounds. Nausea and some vasoconstriction come with it, and it is off the table alongside MAOIs or other serotonergic drugs, or with a cardiac or psychosis history.
Resources
This entry is here for reference.
Research
- 2013first cited2C or not 2C: phenethylamine designer drug review.
- 2019most recentInteractions of phenethylamine-derived psychoactive substances of the 2C-series with human mono…
- 1.Receptor interaction profiles of novel N-2-methoxybenzyl (NBOMe) derivatives of 2,5-dimethoxy-substituted phenethylamines (2C drugs).
- 2.Comparative neuropharmacology of N-(2-methoxybenzyl)-2,5-dimethoxyphenethylamine (NBOMe) hallucinogens and their 2C counterparts in male rats.
- 3.Interactions of phenethylamine-derived psychoactive substances of the 2C-series with human monoamine oxidases.
- 4.2C or not 2C: phenethylamine designer drug review.
- 5.Pharmacology and Toxicology of N-Benzylphenethylamine ("NBOMe") Hallucinogens.
- 6.New phenethylamines in Europe.
6 listed here; entry last updated July 2026
Reviews
My notesprivate to this device
FAQ
How does 2C-C compare to other 2C compounds?
It is generally considered one of the milder, more relaxing and shorter members of the family.
How does it work?
Mainly through agonism at the 5-HT2A serotonin receptor, like the other 2C psychedelics.
What should not be mixed with it?
MAOIs and other strongly serotonergic drugs, because of serotonin toxicity risk.
Adverse effects
- Nausea and some vasoconstriction
- Anxiety or confusion at higher amounts
Notes and cautions
- Easy to misjudge strength