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3C-E is a psychedelic phenethylamine of the mescaline-analog scaline family, the alpha-methylated (amphetamine) homolog of escaline within the 3,4,5-substituted series. It acts as a serotonergic hallucinogen at the 5-HT2A receptor; in mouse head-twitch studies, both alpha-methylation of mescaline-type compounds and homologation of the 4-methoxy group to an ethoxy group increase potency, and the potency relationships observed in mice closely parallel human hallucinogenic data. Compared with escaline, the amphetamine backbone confers greater potency and a longer duration of action with a somewhat more stimulant character. It remains relatively lightly studied in humans.
- Long, visual, introspective psychedelic character
- More potent and longer-acting than escaline
- Alpha-methyl escaline with elevated 5-HT2A head-twitch potency
- Nausea and body load at stronger doses
- Mild stimulant edge adds cardiovascular load
Mechanism
3C-E is a 3,5-dimethoxy-4-ethoxy amphetamine, meaning it is escaline with an extra alpha-methyl group added to the side chain. Its core action is agonism at the receptor, the receptor that drives the classic psychedelic state, with secondary serotonin (5-HT2C) activity. The alpha-methyl group slows metabolic breakdown, which increases potency and lengthens duration relative to the parent phenethylamine.
receptor fingerprint
receptoragonist
5-HT2C receptoragonist
Safetyrisks and cautions, not medical advice
3C-E is long-acting and can be quite intense, with nausea, anxiety, and body load reported at stronger doses; its extended course makes redosing easy to misjudge. As a serotonergic psychedelic it should not be combined with MAOIs or other strongly serotonergic drugs because of serotonin toxicity, and the mild stimulant character adds cardiovascular load. People with heart conditions or a personal or family history of psychosis should avoid it. Not medical advice.
Subjective profileweighing the evidence above
An obscure scaline with only a couple of studies behind it; the alpha-methyl group buys potency and a very long duration, which mostly means more hours of body load and cardiovascular strain. Mescaline is the better-understood version of the same idea.
Resources
This entry is here for reference.
Research
1 listed here; entry last updated August 2026
Reviews
My notesprivate to this device
FAQ
How is 3C-E related to escaline?
It is the amphetamine homolog of escaline, with an extra alpha-methyl group that makes it more potent and longer-acting.
How does it work?
Mainly through agonism at the 5-HT2A serotonin receptor, like other scaline-family psychedelics.
Is it long-lasting?
Yes. It has a slow onset and a long plateau, so redosing is easy to misjudge.
Adverse effects
- Nausea and body load at stronger doses
- Mild stimulant edge adds cardiovascular load
Notes and cautions
- Long duration makes redosing risky