spec sheet10 rows
3C-P is a psychedelic phenethylamine of the mescaline-analog scaline family, the alpha-methylated (amphetamine) homolog of proscaline in the 3,4,5-substituted series. It is a serotonergic hallucinogen acting at the 5-HT2A receptor; in the mouse head-twitch assay, both alpha-methylation and extension of the 4-alkoxy group, here a propoxy substituent, increase potency relative to mescaline, with rodent potency tracking human hallucinogenic data. The propoxy group combined with the amphetamine backbone makes it notably potent and long-acting compared with mescaline itself. It is lightly characterized pharmacologically.
- Long, visual psychedelic character
- More potent and longer-acting than mescaline
- Propoxy scaline amphetamine with high 5-HT2A potency
- Nausea and body load at stronger doses
- Stimulant edge adds cardiovascular load
Mechanism
3C-P is a 3,5-dimethoxy-4-propyloxy amphetamine, essentially proscaline with an extra alpha-methyl group on the side chain. Its core action is agonism at the receptor, the receptor that drives the classic psychedelic state, with secondary activity at 5-HT2C and related serotonin sites. Lengthening the 4-position alkoxy chain to propyl and adding the alpha-methyl both increase potency and duration relative to the shorter scalines.
receptor fingerprint
receptoragonist
5-HT2C receptoragonist
Safetyrisks and cautions, not medical advice
3C-P is potent and long-acting, so misjudging strength is a real hazard, and its extended course makes redosing risky; nausea, anxiety, and body load can appear at stronger doses. As a serotonergic psychedelic it should not be combined with MAOIs or other strongly serotonergic drugs because of serotonin toxicity, and its stimulant character adds cardiovascular load. People with heart conditions or a personal or family history of psychosis should avoid it. Not medical advice.
Subjective profileweighing the evidence above
For experienced psychedelic users only, and even then the duration is the real hazard; a misjudged dose commits you to a very long day with nausea, body load and a stimulant cardiovascular edge. Never combine it with MAOIs or other strongly serotonergic drugs, and do not redose.
Resources
This entry is here for reference.
Research
1 listed here; entry last updated August 2026
Reviews
My notesprivate to this device
FAQ
How is 3C-P related to proscaline?
It is the amphetamine homolog of proscaline, with an extra alpha-methyl group that raises potency and lengthens duration.
How does it work?
Mainly through agonism at the 5-HT2A serotonin receptor, like other scaline-family psychedelics.
Is it more potent than mescaline?
Yes. The propyloxy group and amphetamine backbone make it considerably more potent than mescaline by weight.
Adverse effects
- Nausea and body load at stronger doses
- Stimulant edge adds cardiovascular load
Notes and cautions
- Long duration makes redosing risky