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TMA-2 (2,4,5-trimethoxyamphetamine) is one of the positional isomers of the mescaline-related trimethoxyamphetamine series. Relocating the three methoxy groups to the 2, 4, and 5 ring positions confers far greater potency than mescaline, and it behaves as a classic serotonergic psychedelic acting through 5-HT2A receptor agonism. In rodent models it induces both the head-twitch response and 5-HT2A-dependent locomotor hyperactivity, and comparative head-twitch studies place it among the more potent members of its family while indicating that its 2,4,5 substitution pattern follows a structure-activity relationship distinct from the 3,4,5-substituted analogs. It is lightly studied, with a long duration and a meaningful body load.
- Classic mescaline-like psychedelic character
- Much more potent than the parent TMA
- Long-lasting experience
- 2,4,5-substitution greatly raises potency over mescaline
- Nausea and body load
- Stimulant load; raised heart rate and blood pressure
- Anxiety or confusion at higher strength
Mechanism
TMA-2 is the alpha-methylated (amphetamine) analog of the phenethylamine 2C-O, carrying methoxy groups at the 2, 4, and 5 ring positions; this substitution pattern is highly favorable for binding the receptor, which is why it is much stronger than the 3,4,5 isomer TMA. Its psychedelic effects come from agonism at 5-HT2A, with likely secondary serotonin receptor activity, and the alpha-methyl group slows metabolism, lengthening its action compared with the 2C compounds. Precise human affinity and pharmacokinetic data are limited.
receptor fingerprint
receptoragonist
5-HT2C receptoragonist (presumed)
Safetyrisks and cautions, not medical advice
TMA-2 is considerably more potent than mescaline, so it is easy to overshoot, and its amphetamine backbone adds a stimulant and vasoconstrictive load on the heart and blood pressure. It can produce nausea, anxiety, and confusion, and its long duration is tiring. Combining it with MAOIs or other serotonergic drugs risks serotonin toxicity, and people with cardiovascular problems or a psychosis history should avoid it. Not medical advice.
Subjective profileweighing the evidence above
No improvement on anything and not a beginner's molecule. It is several times stronger than mescaline, so overshooting is easy, and the amphetamine backbone adds a stimulant and vasoconstrictive load on top of a long, tiring duration. Human safety data is thin; anyone with cardiovascular problems or a psychosis history should stay well away.
Resources
This entry is here for reference.
Research
- 2009first citedCreation and application of psychoactive designer drugs data library using liquid chromatograph…
- 2020most recentInvestigation of the 2,5-Dimethoxy Motif in Phenethylamine Serotonin 2A Receptor Agonists.
- 1.Comparison of the behavioral effects of mescaline analogs using the head twitch response in mice.
- 2.Investigation of the 2,5-Dimethoxy Motif in Phenethylamine Serotonin 2A Receptor Agonists.
- 3.Role of the 5-HT₂A receptor in the locomotor hyperactivity produced by phenylalkylamine hallucinogens in mice.
- 4.Creation and application of psychoactive designer drugs data library using liquid chromatography with photodiode array spectrophotometry detector and gas chromatography-mass spectrometry.
4 listed here; entry last updated August 2026
Reviews
My notesprivate to this device
FAQ
How is TMA-2 different from TMA?
The three methoxy groups sit at the 2, 4, and 5 positions rather than 3, 4, and 5, and that pattern makes TMA-2 far more potent.
How does it work?
Mainly through agonism at the 5-HT2A serotonin receptor, like other classic psychedelics.
Does it have a stimulant edge?
Yes, its amphetamine backbone adds a stimulant and vasoconstrictive load on top of the psychedelic effects.
Limitations of the evidence
- Limited human safety data
Adverse effects
- Nausea and body load
- Stimulant load; raised heart rate and blood pressure
- Anxiety or confusion at higher strength