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Proscaline (3,5-dimethoxy-4-propoxyphenethylamine) is a scaline, a homolog of the classic phenethylamine psychedelic mescaline in which the 4-methoxy group is replaced by a longer propoxy chain. Like mescaline it produces its effects chiefly through agonism at the 5-HT2A serotonin receptor, but lengthening the 4-position alkoxy substituent markedly increases potency; comparative studies of mescaline analogs in the mouse head-twitch response confirm that ethoxy and propoxy homologation of the 3,4,5-substituted scaffold raises activity in a manner that parallels the human hallucinogenic data. The resulting experience is described as broadly mescaline-like in character. Because proscaline has been lightly studied, its pharmacokinetics and safety margin are not well defined.
- Classic mescaline-like psychedelic character (presumed)
- More potent than mescaline by weight
- Often described as relatively gentle
- 4-propoxy substitution boosts mescaline-like potency
- Nausea and body load
- Raised heart rate and blood pressure
- Anxiety or confusion at higher strength
Mechanism
Proscaline is a substituted phenethylamine built on the mescaline skeleton, with the para (4) methoxy of mescaline swapped for a longer propyloxy chain; this larger group raises potency substantially over mescaline. Its psychedelic effects come from agonism at the receptor, the receptor that drives the classic psychedelic state, with likely secondary activity at other serotonin receptors such as 5-HT2C. Human pharmacokinetic data are sparse, so precise affinity and duration figures are uncertain.
receptor fingerprint
receptoragonist
5-HT2C receptoragonist (presumed)
Safetyrisks and cautions, not medical advice
As an obscure research psychedelic, Proscaline has no well-established safe range and its potency is higher than mescaline, so misjudging strength is a real hazard. The general psychedelic phenethylamine cautions apply: it can raise heart rate and blood pressure, cause nausea, and provoke intense anxiety or confusion. Combining it with MAOIs or other strongly serotonergic drugs risks serotonin toxicity, and people with a personal or family history of psychosis or serious heart problems should avoid it. Not medical advice.
Subjective profileweighing the evidence above
More potent than mescaline by weight and reportedly gentler in character, but nearly all of that is anecdote rather than measurement, so there is no established safe range. Mescaline itself is the far better documented way to visit the same place.
Resources
This entry is here for reference.
Research
- 2019first citedComparison of the behavioral effects of mescaline analogs using the head twitch response in mice
- 2025most recentMetabolism study of two phenethylamine-derived new psychoactive substances using in silico, in…
- 1.Metabolism study of two phenethylamine-derived new psychoactive substances using in silico, in vivo, and in vitro approaches
- 2.Comparison of the behavioral effects of mescaline analogs using the head twitch response in mice
- 3.The polypharmacology of psychedelics reveals multiple targets for potential therapeutics.
3 listed here; entry last updated August 2026
Reviews
My notesprivate to this device
FAQ
How is Proscaline related to mescaline?
It is a scaline, a mescaline analog with a propyloxy group at the 4-position instead of a methoxy, which makes it more potent by weight.
How does it work?
Mainly through agonism at the 5-HT2A serotonin receptor, the same receptor that drives the classic psychedelic state.
What is the biggest risk?
Misjudging its potency and combining it with MAOIs or other serotonergic drugs, which can cause serotonin toxicity.
Limitations of the evidence
- Limited human safety data
Adverse effects
- Nausea and body load
- Raised heart rate and blood pressure
- Anxiety or confusion at higher strength