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Nimesulide is a sulfonanilide NSAID used for acute pain, osteoarthritis and period pain in the countries that still license it, and restricted or absent in most of the English speaking world because of liver toxicity.
- Fast onset relief in acute pain
- Used for acute pain, osteoarthritis and period pain
- COX-2 preferential with extra effects on neutrophils
- Still licensed across several countries worldwide
- A sulfonanilide, chemically distinct from ordinary NSAIDs
Mechanism
It inhibits COX-2 preferentially and also suppresses neutrophil myeloperoxidase and release, which is where its fast onset in acute pain is thought to come from. The hepatotoxicity is idiosyncratic and not dose related, which is precisely why no monitoring schedule makes it safe.
Safetyrisks and cautions, not medical advice
causes serious and occasionally fatal liver injury; it was never approved in the United States, was withdrawn in Ireland, Spain and Finland, and the EU restricted the rest of its markets to second line use for no more than fifteen days at a time
Subjective profileweighing the evidence above
There is no reason to reach for this over the NSAIDs most of the world still licenses. The liver injury it causes is idiosyncratic rather than dose related, which means no monitoring schedule and no cautious approach makes it safe; a person can do everything right and still be the case. Several regulators looked at the same evidence and withdrew it outright, and that judgement is the one worth following.
Where to buy
Suppliers
Vendors carrying Nimesulide, with live product details and codes. Links are affiliate links that support the wiki at no cost to you.
RUPharma🌐
Nimesulide