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for educational and safety purposes
sci-wiki~$open stack legendary-neuroprotection
nine items in three phases: hold the glutamate brake, shield the mitochondria, then feed the growth signal
9 items; 8 structures drawn from pubchem, 1 drawn generically because pubchem has no record of the name.
The three phases are a real way to think about neuronal death: too much glutamate, too much oxidative load, too little trophic support. Where the roster is strong is that those are genuinely different failure modes, so the items are not four versions of one bet.
What the evidence does not support is the confidence. Every mechanism behind these nine was checked against the primary literature, and the pattern is the same one that runs through this whole family of protocols: a real finding in a rodent or a dish, then a jump to human neuroprotection that nobody has tested. Memantine is the clearest case, because it is the one that HAS been tested: four powered human neuroprotection trials, none positive, and more serious adverse events than placebo in the largest.
The items are ordered by how much is actually known about them rather than by phase, and five carry an optional flag.
Memantine, magnesium and agmatine all act at the NMDA receptor, which is the part of this roster most likely to be additive in a way nobody has measured. Only memantine reaches its target at a realistic dose; agmatine's own binding constant is roughly a thousand times higher than an oral dose achieves, and magnesium's block is already in place physiologically.
The antioxidant layer overlaps heavily with itself. NAC, carnosic acid, PQQ and astaxanthin are four routes to the same endpoint, and running all four is unlikely to add much over running one or two; that is why two carry the optional flag rather than because their evidence is weakest.
Cerebrolysin and NSI-189 are the trophic layer and the least proven pair in the stack.
Nothing here has an acute character except memantine, which is sedating for most people in the first week and is the reason it sits in the evening. Everything else is cumulative and unremarkable to take, which is also what makes a protocol like this hard to judge: there is no signal to tell you it is working.
⚠️ MEMANTINE IS A PRESCRIPTION DRUG AND ITS NEUROPROTECTION RECORD IN HUMANS IS NEGATIVE. Two 48 month phase 3 glaucoma trials in 2,298 patients found no delay in progression, and in a 554 patient motor neurone disease trial serious adverse events ran 20 percent against 13 percent on placebo, with the authors concluding no further testing was warranted. ⚠️ SYSTEMIC MAGNESIUM HAS ALREADY FAILED THE HUMAN TEST IT MATTERS MOST FOR. FAST-MAG gave intravenous magnesium to 1,700 stroke patients, 74 percent of them within the first hour, and the 90 day outcome was identical to placebo; a seven trial meta-analysis concluded routine administration cannot be recommended. ⚠️ CARNOSIC ACID WORKS BY BEING AN ELECTROPHILE, which is the same property that makes its selectivity dose-dependent, and its acceptable daily intake is TEMPORARY specifically pending reproductive and developmental toxicity data. That is roughly 21 milligrams a day for a 70 kilogram adult. NAC increases melanoma metastasis in mice, which is worth knowing for anyone with a personal or family history. Cerebrolysin is not approved by the FDA or EMA for any indication. NSI-189 is investigational and missed its phase 2 primary endpoint. And the general point: almost every positive human result behind these nine has an author employed by the manufacturer. That is not disqualifying on its own, but nothing here should be described as replicated, because almost none of it is.
nothing flaggedcurated roster
every pair here reads as compatible on the mechanisms the site holds. that is the absence of a known conflict, not a clearance.
6 of 9 in one basketAmazon
8 of 9 priced
1 of these carry no listed price, so there is no honest total to print; the lines above are what can actually be costed.
4 overlapssame lever, twice
interested in protocols? join the discord; that is where dosing, timing and the practical side get discussed.
the sci-wiki publishes this as a description of what these compounds do together, not as a recommendation to take them. Nothing here is medical advice.