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the sci-wiki/effects/Recovery

Recovery

Every compound in the sci-wiki that affects recovery; the ones you can source are floated to the front, then the reference-only entries. Tap any for the full entry, mechanism, and outlets.

14 sourced · 13 reference

←recovery27/27filter this drawer by compound name

LGD-4033 + YK-11

LGD-4033 + YK-11 is a research stack that pairs Ligandrol (LGD-4033), a selective androgen receptor modulator, with YK-11, a myostatin-modulating compound, to pursue muscle growth through two mechanisms at once. LGD-4033 activates the androgen receptor and has increased lean body mass in a human trial, while YK-11 raises follistatin to counteract myostatin, the natural brake on muscle growth. For researchers exploring maximal anabolic signaling, this dual-mechanism combination is a frequently discussed and potent pairing.

ATP

Adenosine triphosphate (ATP) is a nucleoside triphosphate that serves as the primary energy-carrying molecule in all living cells, often described as the cell's energy currency. It is built from the nucleobase adenine, the sugar ribose, and a chain of three phosphate groups, and the energy held in its phosphate bonds is released and recaptured as the molecule is interconverted with adenosine diphosphate (ADP). Beyond energy transfer, ATP also acts as a signaling molecule and as a building block for nucleic acids.

Bromelain

Bromelain is a mixture of sulfhydryl (cysteine) proteases and associated non-proteolytic components extracted mainly from the stem and fruit of the pineapple, Ananas comosus. Its anti-inflammatory activity is linked both to its proteolytic action and to downregulation of the NF-kB and mitogen-activated protein kinase signaling pathways, reducing pro-inflammatory cytokines and mediators such as interleukin-1beta, interleukin-6, tumor necrosis factor alpha and prostaglandins. Beyond its long-standing use as an oral supplement for inflammation, digestion and rheumatic complaints, a concentrated bromelain-based preparation (NexoBrid) is an approved agent for rapid, selective enzymatic debridement of deep burn eschar, reducing the need for surgical excision and skin grafting. Additional research has explored anti-thrombotic, fibrinolytic, immunomodulatory and anti-cancer properties, although clinical evidence for many of these uses remains preliminary.

Cardiogen

Cardiogen is a synthetic short peptide marketed as a 'peptide bioregulator' aimed at the cardiovascular system. It belongs to a family of low-molecular-weight peptides developed by Vladimir Khavinson and colleagues at the St. Petersburg Institute of Bioregulation and Gerontology in Russia, who proposed that such peptides help normalize the function of specific tissues as the body ages. Cardiogen is sold as a dietary supplement rather than an approved drug, and rigorous, independent clinical evidence for it is limited.

Glutamine

Glutamine is an alpha-amino acid used in the building of proteins and is the most abundant free amino acid in human blood and muscle. Classified as conditionally essential, it can normally be made by the body but may become depleted during severe illness, injury, or intense stress, when dietary or supplemental intake becomes more important. Beyond its structural role in proteins, glutamine serves as a major carrier of nitrogen between tissues and as a fuel and biosynthetic precursor for rapidly dividing cells such as those of the intestine and immune system.

HMB

HMB, short for beta-hydroxy beta-methylbutyric acid, is a compound the body makes naturally from the essential amino acid leucine. A small fraction of dietary leucine is converted into HMB, which is studied for its role in preserving and building muscle. As a dietary supplement it is sold mainly in a calcium salt form and a free-acid form, and it is used by athletes and older adults for muscle support.

Lactoferrin

Lactoferrin is a multifunctional iron-binding glycoprotein belonging to the transferrin family, found most abundantly in milk and especially in colostrum. It also occurs in tears, saliva, and other secretions and is stored in the white blood cells called neutrophils, forming part of the body's first-line defenses. Best known for its ability to bind iron and for a broad range of antimicrobial and immune-regulating actions, it is added to some infant formulas and sold as a supplement studied mainly for infection and immune support.

Leucine

Leucine is an essential branched-chain amino acid that the body uses to build proteins but cannot make on its own. Along with valine and isoleucine it belongs to the branched-chain group, and it is best known for switching on the cellular machinery that drives muscle protein synthesis. It is obtained from protein-rich foods and is a common ingredient in sports and clinical nutrition supplements.

LGD-4033

LGD-4033, also known as ligandrol or VK5211, is an investigational nonsteroidal selective androgen receptor modulator, a class of compounds abbreviated as SARM. It binds the androgen receptor, the same target acted on by testosterone, but is designed to stimulate muscle and bone while having weaker effects on other tissues. First described by Ligand Pharmaceuticals and later developed by Viking Therapeutics, it has been studied for muscle wasting but is not approved for any medical use, and it is banned in sport and sold illicitly to bodybuilders.

Modified GRF 1-29

Modified GRF 1-29 is a synthetic peptide analog of growth hormone-releasing hormone (GHRH), built from the first 29 amino acids of GHRH with four amino acid substitutions that make it more resistant to breakdown. It is closely related to sermorelin and to CJC-1295; in fact it is the short-acting form of CJC-1295, lacking the albumin-binding attachment (the drug affinity complex, or DAC) that gives the latter its long duration. Like other GHRH analogs it prompts the pituitary gland to release growth hormone, and it is handled as a research chemical rather than an approved medicine.

MSM

MSM (methylsulfonylmethane), also known as dimethyl sulfone, is a naturally occurring organosulfur compound and oxidation product of dimethyl sulfoxide that is present in trace amounts in many foods and is widely sold as a dietary supplement. Its reported anti-inflammatory and antioxidant actions are attributed to suppression of NF-kB signaling and downstream pro-inflammatory mediators, together with scavenging of reactive oxygen species and support of endogenous antioxidant capacity. Several randomized controlled trials in knee osteoarthritis report modest improvements in pain and physical function, and the compound is generally recognized as safe and well tolerated at doses of up to several grams daily. Preclinical studies have additionally examined effects on exercise-related oxidative stress, allergic inflammation and cancer-cell biology, including induction of apoptosis and sensitization of tumor cells to chemotherapy, though the overall clinical evidence base remains limited.

Palmitoylethanolamide

Palmitoylethanolamide (PEA) is a naturally occurring fatty acid amide belonging to the N-acylethanolamine family. Produced in the body and also found in foods, it acts largely by activating the nuclear receptor PPAR-alpha and by dampening the activity of inflammatory cells such as mast cells. It has been studied mainly for chronic pain, inflammation, and neuroprotection, and it is sold as a dietary supplement or food for special medical purposes rather than as a conventional drug.

PEG-MGF

PEG-MGF is a stability-engineered form of mechano growth factor (MGF), a splice variant of the IGF-1 gene that is switched on in muscle by mechanical loading and damage. Its C-terminal peptide is proposed to act as an early trigger that activates satellite (muscle stem) cells for repair before systemic IGF-1 takes over, and attaching a polyethylene glycol group is intended to extend its very short circulating life. Whether the synthetic C-terminal MGF peptide has genuine biological activity is still scientifically disputed, with published studies on both sides, and PEG-MGF remains an unapproved research peptide.

Wolverine Stack

The Wolverine Stack is a popular regenerative peptide combination that pairs BPC-157 with TB-500, named for the comic-book mutant famous for his near-instant healing. It brings together two of the most sought-after recovery peptides: BPC-157, a gastric peptide that accelerates tendon, ligament, muscle, and gut healing, and TB-500, a thymosin beta-4 peptide that drives cell migration and new blood vessel growth. Marketed to athletes and biohackers chasing faster injury recovery, the stack is prized for its complementary, tissue-repairing effects.

reference shelf; no outlet carries these yet

RAD-140 + YK-11

RAD-140 (Testolone) plus YK-11 is a popular bodybuilding stack that pairs two selective androgen receptor modulators (SARMs) sought for rapid gains in muscle mass and strength [1]. RAD-140 is a potent nonsteroidal androgen receptor agonist designed to drive muscle growth with fewer of the prostate and hormonal effects of testosterone, while YK-11 is a steroidal SARM marketed as a myostatin-modulating muscle-builder [1][7]. Both are investigational research chemicals, not approved drugs, and both are banned in sport; importantly, RAD-140 has been linked in case reports to serious cardiac harm, so the stack carries real risk [1][2][3].

BCAAs

Branched-chain amino acids (BCAAs) are a group of three essential amino acids, leucine, isoleucine, and valine, named for the branched shape of their molecular side chains. They cannot be made by the body and must come from protein in the diet, and they make up a large share of the amino acids in muscle. They are sold widely as sports supplements for muscle growth and recovery, with leucine in particular acting as a trigger for muscle protein synthesis, though the value of taking them in isolation is debated.

Casein Protein

Casein is the main protein in milk, making up roughly 80 percent of the protein in cow's milk. It is a family of phosphoproteins that clump together into microscopic clusters called micelles, and it is the component of milk that curdles to form cheese. As a nutritional supplement, casein is valued as a slow-digesting protein that releases amino acids gradually over several hours, which has made it popular for muscle recovery and as a protein taken before sleep.

Collagen Peptides

Collagen peptides, also called hydrolyzed collagen or collagen hydrolysate, are short chains of amino acids produced by breaking down collagen, the main structural protein of animal skin, bone and connective tissue [1]. Sold as a nearly tasteless, water-soluble powder made from bovine, porcine or fish sources, they are a popular dietary supplement marketed for skin, joint, bone and nail health [1]. Several controlled trials have reported improvements in skin elasticity, hydration and wrinkles with regular intake, while claims for joints and bones rest on more limited evidence [2][3][4].

Ginger

Ginger is the rhizome of Zingiber officinale, a flowering herbaceous perennial in the family Zingiberaceae that has served for millennia as both a culinary spice and a folk remedy. Native to Maritime Southeast Asia, where Austronesian peoples are thought to have first domesticated it, the plant is prized for its pungent, aromatic root, whose flavor derives chiefly from gingerols and related shogaols. Ginger is used fresh, dried, powdered, pickled, or candied, and among its many traditional uses it is most studied for easing nausea.

IGF-1

Insulin-like growth factor 1 (IGF-1), also called somatomedin C, is a peptide hormone that is structurally close to insulin and serves as the principal mediator of growth hormone action. Produced chiefly by the liver but also locally in tissues, it signals through the IGF-1 receptor to drive cell proliferation, differentiation, and protein synthesis, and it feeds back on the hypothalamus and pituitary to help regulate the growth hormone axis. A notable feature is the alternative splicing of the IGF-1 gene in skeletal muscle to yield mechano growth factor, a variant rapidly induced by mechanical loading or injury that is associated with satellite (stem) cell activation and repair, though its distinct peptide activity remains debated. A recombinant form, mecasermin, is an approved therapy for children with severe primary IGF-1 deficiency, and the hormone remains a central focus in research on aging, longevity, neuroprotection, and cancer risk.

Lactase

Lactase is a digestive enzyme, a type of β-galactosidase, that breaks the milk sugar lactose into the simpler sugars glucose and galactose so they can be absorbed. In mammals it is produced by cells lining the small intestine and is most active in infancy. In many people its activity falls after weaning, leading to lactose intolerance, and the enzyme is manufactured commercially as a supplement and used to make lactose-free dairy foods.

Laminarin

Laminarin is a storage polysaccharide, a type of β-glucan, that brown algae such as kelp accumulate as an energy reserve. It is built from chains of glucose joined mainly by β-1,3 bonds with occasional β-1,6 branches. Abundant in the ocean and important to the marine carbon cycle, laminarin has drawn interest for a range of biological activities, including effects on the immune system and the gut, and it is studied as a marine-derived ingredient rather than an approved drug.

Lipase

Lipase is any of a broad class of enzymes that break down fats by splitting triglycerides into fatty acids and glycerol. In the human body, lipases produced mainly by the pancreas carry out much of the digestion of dietary fat, and the enzyme occurs throughout the living world in animals, plants, and microbes. Beyond digestion, blood lipase levels are used to diagnose pancreatitis, and lipase preparations are taken as digestive aids and used widely in industry.

Research Chemical

MK-3984

MK-3984 is an experimental selective androgen receptor modulator (SARM) developed by Merck. Like other SARMs it was designed to switch on the androgen receptor selectively in muscle and bone while largely sparing tissues such as the prostate, with the goal of treating conditions like muscle wasting and osteoporosis. It never reached clinical use, its development was discontinued, and today it is encountered mainly as a research chemical.

Protease

A protease is an enzyme that breaks down proteins by cleaving the peptide bonds that link amino acids together, a process known as proteolysis. Proteases occur in all living things, where they carry out tasks ranging from digesting food to controlling blood clotting, immune responses, and cell signalling. They are grouped into several families according to the chemical machinery in their active site, and outside the body they are used in detergents, food processing, and as digestive enzyme supplements.

Turkesterone

Turkesterone is a phytoecdysteroid, a plant steroid structurally related to the insect moulting hormone 20-hydroxyecdysone, found most notably in the herb Ajuga turkestanica. It is chemically the 11-alpha-hydroxy analogue of 20-hydroxyecdysone and has been promoted as a natural dietary supplement for building muscle. Despite this marketing, its pharmacokinetics and effects in humans remain largely uncharacterised, and controlled human trials are lacking [1][2].

Whey Protein Isolate

Whey protein isolate is a dietary supplement made from whey, the liquid left over when milk is curdled during cheese production. It is a highly refined form of whey protein, processed to remove most of the fat and lactose so that the powder is typically over ninety percent protein by weight, which distinguishes it from the less concentrated whey protein concentrate. Rich in essential amino acids and particularly in leucine, it is widely used in sports nutrition and in clinical settings to support muscle protein synthesis.