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A synthetic progestin (a 16alpha,17alpha-dihydroxy derivative of progesterone) that was never marketed on its own. Its ester, algestone acetophenide, went on to become a marketed injectable contraceptive in some countries.
- Served as the chemical basis for algestone acetophenide, a marketed injectable contraceptive used in some countries
- Demonstrates strong progesterone receptor binding characteristic of an active progestin
- Its marketed ester form is associated with typical progestin side effects such as irregular bleeding
Overview
Never sold itself, but it's the chemical backbone behind a real-world contraceptive injection once you add an acetophenide ester onto it.
Mechanism
Algestone binds and activates the progesterone receptor, mimicking the effects of endogenous progesterone on the endometrium and the hypothalamic-pituitary-gonadal axis, the hormonal feedback loop that regulates the reproductive cycle.
receptor fingerprint
Progesterone receptorAgonist
Safetyrisks and cautions, not medical advice
Algestone itself has no dedicated human safety record since it was never marketed. Its ester, algestone acetophenide, used clinically as an injectable contraceptive, shows the menstrual irregularities and weight changes typical of progestin-only contraceptives.
Subjective profileweighing the evidence above
Nothing to use here. It was never marketed on its own and has no dedicated human record; only its ester became a real injectable contraceptive, and that carries the usual progestin bleeding and weight changes. Of chemical interest only.
Resources
This entry is here for reference.
Reviews
My notesprivate to this device
FAQ
What is Algestone used for?
Algestone itself was never marketed; its main significance is as the chemical parent of algestone acetophenide, a marketed injectable contraceptive.
How does Algestone work?
It binds to and activates the progesterone receptor, mimicking the hormone progesterone's effects on the reproductive system.
Is Algestone well-researched?
Not extensively on its own; most available data concerns its marketed ester derivative, algestone acetophenide, rather than algestone itself.
Limitations of the evidence
- Never tested independently in humans, so no dedicated safety profile exists
Adverse effects
- Its marketed ester form is associated with typical progestin side effects such as irregular bleeding