spec sheet4 rows
Midecamycin is a 16 membered macrolide antibiotic used mainly for respiratory, skin and atypical genitourinary infection; it is registered in Russia, Japan and parts of Europe and has never been marketed in the United States or the United Kingdom.
- A 16 membered macrolide for respiratory and skin infection
- Reaches atypical genitourinary infection as well
- Binds the 50S subunit and blocks bacterial translocation
- Registered in Russia, Japan and parts of Europe
- A macrolide rarely seen on American or British shelves
Mechanism
It binds the 50S ribosomal subunit and blocks the translocation step of bacterial protein synthesis, which stops growth rather than killing the organism outright. Cross resistance with erythromycin through methylated 23S rRNA is common, so a macrolide resistant isolate is usually resistant to this one too.
Safetyrisks and cautions, not medical advice
an antibiotic; unnecessary or truncated courses drive macrolide resistance, and it needs a bacterial diagnosis rather than a guess
Subjective profileweighing the evidence above
Cross resistance is the practical problem: methylated 23S rRNA disables the whole macrolide class at once, so an organism that shrugged off erythromycin will shrug off this one, and reaching for a less familiar macrolide buys no second chance. Where a susceptible organism has actually been identified there is nothing wrong with the drug; it is registered in Russia, Japan and parts of Europe and has simply never been marketed in the US or UK. Antibiotics bought on a guess are how the resistance problem gets built, one truncated course at a time.
Where to buy
Suppliers
Vendors carrying Midecamycin, with live product details and codes. Links are affiliate links that support the wiki at no cost to you.
RUPharma🌐
Midecamycin