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Methallylescaline (MAL) is a psychedelic phenethylamine of the mescaline-analog scaline family, bearing a methallyloxy group at the 4 position of the ring. It acts as an agonist at serotonin 5-HT2 receptors, producing a mescaline-like psychedelic state that is more potent by weight than mescaline and often reported as visually rich. Controlled rodent work has used it to probe the receptor basis of the head-twitch response, finding that while 5-HT2A activation is the principal trigger, 5-HT2C receptors also contribute distinctly to the behavior; the same study reported dose-dependent neurotoxic and pro-inflammatory effects at high exposures. It remains lightly studied, so its safety margin in humans is uncertain.
- Mescaline-like, visually rich psychedelic character
- More potent than mescaline by weight
- Head-twitch response driven by both 5-HT2A and 5-HT2C
- Higher potency than mescaline raises dosing-error risk
- Nausea and body load
Mechanism
Methallylescaline is a 3,5-dimethoxy-4-methallyloxy phenethylamine, a close relative of mescaline and allylescaline where the 4-position bears a branched, unsaturated methallyl ether. Its core action is agonism at the receptor, the receptor that drives the classic psychedelic state, with secondary serotonin (5-HT2C) activity. The larger, unsaturated 4-position group raises 5-HT2A affinity, making it more potent than mescaline by weight.
receptor fingerprint
receptoragonist
5-HT2C receptoragonist
Safetyrisks and cautions, not medical advice
Methallylescaline is more potent than mescaline and only lightly studied, so its safe range is not well defined and dosing errors are easy; nausea and body load are commonly reported. As a serotonergic psychedelic it should not be combined with MAOIs or other strongly serotonergic drugs because of serotonin toxicity. People with heart conditions or a personal or family history of psychosis should avoid it. Not medical advice.
Subjective profileweighing the evidence above
Mescaline-like and visually rich, but stronger by weight than mescaline and only lightly studied, which is a bad pairing for something measured by hand. Nausea and body load are routine, and the usual exclusions for cardiac conditions and psychosis history apply.
Resources
This entry is here for reference.
Research
- 1.Metabolism study of two phenethylamine-derived new psychoactive substances using in silico, in vivo, and in vitro approaches.
- 2.Serotonin 2C receptors are also important in head-twitch responses in male mice.
2 listed here; entry last updated August 2026
Reviews
My notesprivate to this device
FAQ
How is methallylescaline related to mescaline?
It is a scaline analog with a branched methallyloxy group at the 4 position, which makes it more potent than mescaline by weight.
How does it work?
Mainly through agonism at the 5-HT2A serotonin receptor, like other scaline-family psychedelics.
Is it well studied?
No. It is lightly characterized, so its safe range is not precisely established.
Limitations of the evidence
- Limited human safety data
Adverse effects
- Higher potency than mescaline raises dosing-error risk
- Nausea and body load