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Dexamethasone + Neomycin + Polymyxin B Maxitrol is a combination eye drop of the corticosteroid dexamethasone with two antibiotics, neomycin and polymyxin B, used where eye inflammation coexists with a risk of bacterial infection.
- Maxitrol pairs a potent steroid with two antibiotics
- Calms eye inflammation while covering bacterial risk
- Polymyxin B adds gram negative cover
- Neomycin and polymyxin B span a broad bacterial range
- Three actives delivered in a single eye drop
Mechanism
Dexamethasone shuts down the inflammatory transcription programme, neomycin binds the bacterial 30S ribosome and causes mistranslation, and polymyxin B disrupts the outer membrane of Gram negative organisms. The pairing exists because a steroid used alone would let a bacterial infection run unchecked.
Safetyrisks and cautions, not medical advice
a corticosteroid plus two antibiotics; the steroid component worsens herpetic and fungal eye infection and raises intraocular pressure with prolonged use
Subjective profileweighing the evidence above
Putting a potent steroid into an eye without knowing why the eye is red is how a herpes simplex dendritic ulcer becomes a corneal scar, and that single scenario is why this combination should never live in a bathroom cabinet as a standby. The antibiotics are in the bottle precisely because the steroid strips out the response that would otherwise contain an infection, which is a fair measure of how much the steroid is doing. Neomycin is also among the commonest contact sensitisers, so drops that stop helping and start itching may be an allergy to the treatment rather than a worsening infection. Prolonged use raises intraocular pressure silently, and nobody notices that at home.
Where to buy
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Dexamethasone + Neomycin + Polymyxin B
