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25E-NBOH is the N-(2-hydroxybenzyl) derivative of 2C-E and a comparatively recent entrant to the NBOH class of serotonergic hallucinogens. The 2-hydroxybenzyl substituent markedly increases 5-HT2A receptor affinity and agonist potency over the parent 2C-E, rendering the compound active at small doses. Human liver microsome and authentic-sample studies have mapped its phase I and phase II metabolism, identifying O-demethylation, hydroxylation, and glucuronidation products proposed as consumption markers, information relevant to detection given the thermolability common to NBOHs. A documented serotonin-syndrome intoxication, in which powder sold as 25I-NBOH was analytically confirmed to contain 25E-NBOH, illustrates both its clinical toxicity and the frequent mislabeling seen in this drug market.
- Potent 5-HT2A agonist derived from 2C-E
- Slightly gentler reputation than the NBOMe series
- Potent 5-HT2A agonist of the 4-ethyl NBOH series
- Vasoconstriction and high blood pressure
- Seizures and severe agitation
Mechanism
25E-NBOH is 2C-E (the 4-ethyl phenethylamine) with a 2-hydroxybenzyl group added to the nitrogen, which sharply increases affinity and potency at the receptor underlying the psychedelic state. As an NBOH compound it is somewhat less stable and generally regarded as marginally less potent than the matching NBOMe, but it remains a strong agonist with secondary 5-HT2C activity. It is broken down in the gut, so it is inactive when swallowed.
receptor fingerprint
receptoragonist
5-HT2C receptoragonist
Safetyrisks and cautions, not medical advice
25E-NBOH is active at small amounts, so the margin for error is narrow and careful measurement matters. The N-benzyl phenethylamines can cause dangerous vasoconstriction, high blood pressure, seizures, severe agitation, and heart problems, and the family has caused deaths. It must never be combined with stimulants, vasoconstrictors, or serotonergic drugs, and it may be mis-sold as LSD; people with heart problems or a psychosis history should avoid it. Not medical advice.
Subjective profileweighing the evidence above
The NBOH family's gentler reputation is relative, not safe; these compounds cause seizures and dangerous vasoconstriction, the class has killed people, and this one is active at doses where guessing gets you hurt. Better-characterized psychedelics do the same job without the risk.
Resources
This entry is here for reference.
Research
- 2018first citedNeurochemical pharmacology of psychoactive substituted N-benzylphenethylamines: High potency ag…
- 2024most active year3 papers
- 2025most recentLocomotor and discriminative stimulus effects of NBOH hallucinogens in rodents
- 1.Severe 25E-NBOH intoxication associated with MDPHP intake: a case report, metabolism study, and literature review
- 2.Locomotor and discriminative stimulus effects of NBOH hallucinogens in rodents
- 3.Metabolic characterization of 25X-NBOH and 25X-NBOMe phenethylamines based on UHPLC-Q-Exactive Orbitrap MS in human liver microsomes.
- 4.Novel disposable and portable 3D-printed electrochemical apparatus for fast and selective screening of 25E-NBOH in forensic samples.
- 5.Neurochemical pharmacology of psychoactive substituted N-benzylphenethylamines: High potency agonists at 5-HT2A receptors.
5 listed here; entry last updated August 2026
Reviews
My notesprivate to this device
FAQ
How is 25E-NBOH different from 2C-E?
It is 2C-E with an added N-benzyl group that makes it far more potent and narrows the margin for error.
Can you swallow it?
No, it is broken down in the gut and is inactive orally; it is used sublingually.
Why is it dangerous?
It is active at small amounts and can cause vasoconstriction, seizures, and heart problems.
Adverse effects
- Vasoconstriction and high blood pressure
- Seizures and severe agitation
Notes and cautions
- Narrow safety margin
- May be mis-sold as LSD