spec sheet10 rows
25C-NBOH is the N-(2-hydroxybenzyl) derivative of 2C-C and a member of the NBOH class of potent 5-HT2A receptor agonists. As with other N-benzyl phenethylamines, the added benzyl substituent greatly enhances 5-HT2A affinity and agonist efficacy relative to the parent 2C-C, producing hallucinogenic activity at very low doses. Experimental studies have shown that 25C-NBOH and the related 25I-NBOH exert direct adverse effects on the cardiovascular system, and rodent work characterizes their locomotor and discriminative-stimulus profiles as consistent with 5-HT2A-mediated hallucinogens. Because the NBOH structure is thermolabile and degrades to its 2C precursor under gas chromatography, specialized analytical methods are needed for its detection; it is orally inactive and typically used sublingually, and it has been misrepresented as LSD.
- Very potent 5-HT2A agonist
- Slightly gentler reputation than the NBOMe series
- Potent 5-HT2A agonist with documented cardiovascular effects
- Vasoconstriction and high blood pressure
- Seizures and severe agitation
Mechanism
25C-NBOH is 2C-C (the 4-chloro phenethylamine) with a 2-hydroxybenzyl group added to the nitrogen, which sharply increases affinity and potency at the receptor that underlies the classic psychedelic state. Like other NBOH compounds it is somewhat less stable and generally regarded as marginally less potent than the matching NBOMe, but it is still an extremely strong agonist with secondary 5-HT2C activity. It is broken down in the gut, so it is inactive when swallowed.
receptor fingerprint
receptoragonist
5-HT2C receptoragonist
Safetyrisks and cautions, not medical advice
25C-NBOH is active at very small amounts, so the gap between a common and a hazardous quantity is small and careful measurement matters. The NBOH and NBOMe compounds can cause dangerous vasoconstriction, high blood pressure, seizures, severe agitation, and heart problems, and deaths have occurred. It must never be combined with stimulants, vasoconstrictors, or serotonergic drugs, and because it is often mis-sold as LSD a blotter is not proof of its identity; people with heart problems or a psychosis history should avoid it. Not medical advice.
Subjective profileweighing the evidence above
Not worth it. Active in micrograms, with documented cardiovascular harm, seizures, severe agitation and deaths in this family, and it is routinely mis-sold as LSD so people take it without knowing. A slightly gentler reputation than the NBOMes does not make it safe.
Resources
This entry is here for reference.
Research
- 2006first citedMolecular interaction of serotonin 5-HT2A receptor residues Phe339(6.51) and Phe340(6.52) with…
- 2025most recentLocomotor and discriminative stimulus effects of NBOH hallucinogens in rodents.
- 1.Locomotor and discriminative stimulus effects of NBOH hallucinogens in rodents.
- 2.Molecular interaction of serotonin 5-HT2A receptor residues Phe339(6.51) and Phe340(6.52) with superpotent N-benzyl phenethylamine agonists.
- 3.2-((2-(4-Iodo-2,5-dimethoxyphenyl)ethylamino)methyl)phenol (25I-NBOH) and 2-(((2-(4-chloro-2,5-dimethoxyphenyl)ethyl)amino)methyl)phenol (25C-NBOH) induce adverse effects on the cardiovascular system.
- 4.Neurochemical pharmacology of psychoactive substituted N-benzylphenethylamines: High potency agonists at 5-HT2A receptors.
- 5.Metabolic characterization of 25X-NBOH and 25X-NBOMe phenethylamines based on UHPLC-Q-Exactive Orbitrap MS in human liver microsomes.
- 6.Detection of 25C-NBOMe in Three Related Cases.
- 7.Pharmacology and Toxicology of N-Benzylphenethylamine ("NBOMe") Hallucinogens.
7 listed here; entry last updated August 2026
Reviews
My notesprivate to this device
FAQ
How is 25C-NBOH different from 2C-C?
It is 2C-C with an added N-benzyl group that makes it enormously more potent and narrows the margin for error.
Can you swallow it?
No, it is destroyed in the gut and is essentially inactive orally; it is used sublingually.
Why is it dangerous?
It is active at tiny amounts, can cause vasoconstriction, seizures, and heart problems, and is often mis-sold as LSD.
Adverse effects
- Vasoconstriction and high blood pressure
- Seizures and severe agitation
Notes and cautions
- Very narrow safety margin
- Often mis-sold as LSD