spec sheet10 rows
25C-NBOMe is the N-(2-methoxybenzyl) derivative of 2C-C and one of the most frequently encountered members of the NBOMe family. The 2-methoxybenzyl substitution confers high, near-subnanomolar affinity and full agonist activity at the 5-HT2A receptor, so the compound is active at microgram doses and is distributed on blotter paper, often after being mis-sold as LSD. It is subject to extensive first-pass metabolism and is used sublingually rather than orally. A substantial forensic and clinical literature documents severe and fatal intoxications, in which vasoconstriction, seizures, hyperthermia, metabolic acidosis, rhabdomyolysis, and multi-organ failure are recurrent features.
- Extremely potent, stimulating 5-HT2A agonist
- One of the more studied NBOMe compounds
- Extremely potent 5-HT2A agonist active at microgram doses
- Severe vasoconstriction and high blood pressure
- Seizures, hyperthermia, and cardiac problems
Mechanism
25C-NBOMe is 2C-C with a 2-methoxybenzyl group on the nitrogen, a modification that greatly increases binding affinity and potency at the receptor responsible for the psychedelic state. Its effects, both psychedelic and physiological, stem from powerful 5-HT2A agonism with additional 5-HT2C activity. The compound is broken down in the gut, so it is inactive orally and is taken sublingually or by other non-oral routes.
receptor fingerprint
receptoragonist
5-HT2C receptoragonist
Safetyrisks and cautions, not medical advice
25C-NBOMe is active at extremely small amounts, so small measurement errors can be dangerous and the safety margin is very narrow. It can cause severe vasoconstriction, dangerously high blood pressure, seizures, agitation, hyperthermia, and cardiac problems, and deaths have been reported. It must never be combined with stimulants, vasoconstrictors, or serotonergic drugs, and because it is frequently mis-sold as LSD, a blotter is not proof of its identity; people with heart problems or a psychosis history should avoid it. Not medical advice.
Subjective profileweighing the evidence above
Avoid this one. Active at micrograms with a very narrow margin, repeatedly mis-sold as LSD, and the forensic literature is full of seizures, hyperthermia, organ failure and deaths. It offers nothing a better characterised psychedelic does not, at far worse odds.
Resources
This entry is here for reference.
Research
- 2014first citedTwo cases of severe intoxication associated with analytically confirmed use of the novel psycho…
- 2015most active year4 papers
- 2023most recentFatal Intoxications from a Combination of 4-Fluoroamphetamine and 25C-NBOMe.
- 1.Toxicities associated with NBOMe ingestion-a novel class of potent hallucinogens: a review of the literature
- 2.Two cases of severe intoxication associated with analytically confirmed use of the novel psychoactive substances 25B-NBOMe and 25C-NBOMe
- 3.Receptor interaction profiles of novel N-2-methoxybenzyl (NBOMe) derivatives of 2,5-dimethoxy-substituted phenethylamines (2C drugs).
- 4.Pharmacology and Toxicology of N-Benzylphenethylamine ("NBOMe") Hallucinogens.
- 5.Evolution of the NBOMes: 25C- and 25B- Sold as 25I-NBOMe.
- 6.Near fatal intoxication with the novel psychoactive substance 25C-NBOMe.
- 7.Fatal intoxication with the new designer drug 25C-NBOMe.
- 8.Death after 25C-NBOMe and 25H-NBOMe consumption.
- 9.Detection of 25C-NBOMe in Three Related Cases.
- 10.Fatal Intoxications from a Combination of 4-Fluoroamphetamine and 25C-NBOMe.
- 11.Metabolic fate and detectability of the new psychoactive substances 2-(4-bromo-2,5-dimethoxyphenyl)-N-[(2-methoxyphenyl)methyl]ethanamine (25B-NBOMe) and 2-(4-chloro-2,5-dimethoxyphenyl)-N-[(2-methoxyphenyl)methyl]ethanamine (25C-NBOMe) in human and rat urine by GC-MS, LC-MS(n), and LC-HR-MS/MS approaches.
11 listed here; entry last updated August 2026
Reviews
My notesprivate to this device
FAQ
How is 25C-NBOMe different from 2C-C?
It is 2C-C with an N-methoxybenzyl group that makes it far more potent and much more dangerous.
Can you swallow it?
No, it is broken down in the gut and is inactive orally; it is used sublingually.
Why is it so risky?
It is active at tiny amounts, has a narrow margin, can cause seizures and heart problems, and is often mis-sold as LSD.
Adverse effects
- Severe vasoconstriction and high blood pressure
- Seizures, hyperthermia, and cardiac problems
Notes and cautions
- Very narrow safety margin
- Frequently mis-sold as LSD