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25D-NBOMe is the N-(2-methoxybenzyl) derivative of 2C-D and a member of the potent NBOMe hallucinogen class. The N-benzyl group converts the comparatively mild 2C-D into a strong 5-HT2A receptor agonist active at small doses, with a narrow safety margin shared across the series. Beyond serotonergic action, controlled rodent studies indicate that 25D-NBOMe produces reinforcing and rewarding effects mediated by changes in dopaminergic neurotransmission, suggesting an abuse-liability dimension not always associated with classical psychedelics. It is orally inactive owing to extensive first-pass metabolism, is used sublingually, and has been identified as a minor constituent of NBOMe blotter products.
- Potent 5-HT2A agonist derived from the milder 2C-D
- Stimulating psychedelic character
- 5-HT2A agonist with reward-linked dopaminergic actions
- Vasoconstriction and high blood pressure
- Seizures and severe agitation
Mechanism
25D-NBOMe is 2C-D (the 4-methyl phenethylamine) with a 2-methoxybenzyl group added to the nitrogen; this substitution greatly raises binding affinity and potency at the receptor that drives the psychedelic state. Its psychedelic and physiological effects come from strong 5-HT2A agonism, with additional 5-HT2C activity. Like the rest of the family it is broken down in the gut and is therefore inactive when swallowed.
receptor fingerprint
receptoragonist
5-HT2C receptoragonist
Safetyrisks and cautions, not medical advice
25D-NBOMe is active at small amounts, so the margin between a common and a hazardous quantity is narrow and measurement matters. NBOMe compounds can cause dangerous vasoconstriction, high blood pressure, seizures, severe agitation, hyperthermia, and heart problems, and the family has caused deaths. It must never be combined with stimulants, vasoconstrictors, or serotonergic drugs, and it may be mis-sold as LSD; people with heart problems or a psychosis history should avoid it. Not medical advice.
Subjective profileweighing the evidence above
Not worth it under any framing. The NBOMe family is active at microgram scale with a narrow safety margin, has caused deaths through vasoconstriction, seizures and hyperthermia, and is often mis-sold as LSD to people expecting a much safer drug.
Resources
This entry is here for reference.
Research
- 2014first citedEffects of the hallucinogen 2,5-dimethoxy-4-iodophenethylamine (2C-I) and superpotent N-benzyl…
- 2023most recentDesigner Drug, 25D-NBOMe, Has Reinforcing and Rewarding Effects through Change of a Dopaminergi…
- 1.2-(2,5-Dimethoxy-4-methylphenyl)-N-(2-methoxybenzyl)ethanamine (25D-NBOMe) and N-(2-methoxybenzyl)-2,5-dimethoxy-4-chlorophenethylamine (25C-NBOMe) induce adverse cardiac effects in vitro and in vivo.
- 2.Designer Drug, 25D-NBOMe, Has Reinforcing and Rewarding Effects through Change of a Dopaminergic Neurochemical System.
- 3.In vitro phase I metabolism of three phenethylamines 25D-NBOMe, 25E-NBOMe and 25N-NBOMe using microsomal and microbial models.
- 4.Receptor interaction profiles of novel N-2-methoxybenzyl (NBOMe) derivatives of 2,5-dimethoxy-substituted phenethylamines (2C drugs).
- 5.Pharmacology and Toxicology of N-Benzylphenethylamine ("NBOMe") Hallucinogens.
- 6.Effects of the hallucinogen 2,5-dimethoxy-4-iodophenethylamine (2C-I) and superpotent N-benzyl derivatives on the head twitch response.
- 7.Analysis of 25I-NBOMe, 25B-NBOMe, 25C-NBOMe and Other Dimethoxyphenyl-N-[(2-Methoxyphenyl) Methyl]Ethanamine Derivatives on Blotter Paper.
7 listed here; entry last updated August 2026
Reviews
My notesprivate to this device
FAQ
How is 25D-NBOMe different from 2C-D?
It is 2C-D with an added N-methoxybenzyl group that makes it far more potent and much more dangerous.
Can you swallow it?
No, it is broken down in the gut and is inactive orally; it is used sublingually.
Why is it dangerous?
It is active at small amounts, has a narrow margin, and can cause vasoconstriction, seizures, and heart problems.
Limitations of the evidence
- Narrow safety margin
Adverse effects
- Vasoconstriction and high blood pressure
- Seizures and severe agitation
Notes and cautions
- May be mis-sold as LSD