Liver: nootropics and compounds | sci-wiki

5-Amino/MIC

5-Amino/MIC is a combination formulation that pairs the NNMT inhibitor 5-Amino-1MQ with the classic lipotropic trio MIC, namely methionine, inositol, and choline. It is designed to attack body fat from two directions at once; 5-Amino-1MQ reprograms fat-cell metabolism by raising NAD, while the MIC lipotropics support the liver's handling and export of fat. Popular in physique and weight-management circles, it bundles a modern metabolic target with time-tested fat-metabolism cofactors in a single stack.

1 outlet

Blend

Lipo MIC Prime

Lipo MIC Prime is a lipotropic injectable that combines the classic MIC nutrients (methionine, inositol, and choline) with L-carnitine and vitamin B12 to support fat metabolism and energy during weight management. The MIC compounds help the liver process and export fat, L-carnitine ferries fatty acids into the mitochondria to be burned, and B12 supports energy production and methylation. Bundling several complementary metabolic cofactors into one formulation, it is a convenient, nutrient-based adjunct to a diet-and-exercise program.

1 outlet

Mitochondrial

DADA

DADA is diisopropylamine dichloroacetate, an old liver drug sold in Japan for decades as Liverall and also sold in the West under the discredited "vitamin B15" or pangamic acid label; it is a simple salt that separates in the body into diisopropylamine and dichloroacetate. The dichloroacetate half blocks an enzyme called pyruvate dehydrogenase kinase, which pushes cells away from making lactate and toward burning fuel in the mitochondria; that single mechanism is why nearly all recent work on it is cancer and immune metabolism research in mice and cell dishes. Human evidence is thin; the only controlled human trial found is a 2005 Chinese study in fatty liver disease that compared 60 mg and 120 mg per day against each other with no placebo group, so it cannot show the drug beats doing nothing. It is not a dopamine drug, has no reported activity at dopamine receptors, and no study of any kind was found testing it for memory, mood, focus, or athletic performance.

2 outlets

Flavonoid

Dihydromyricetin

Dihydromyricetin (DHM, also called ampelopsin) is a flavonoid from the oriental raisin tree (Hovenia dulcis) and the vine Ampelopsis grossedentata, used for centuries in East Asian folk medicine as a hangover and liver remedy. It is best known for two overlapping effects: modulating GABA-A receptors to counter alcohol's actions on the brain, and supporting the liver enzymes that clear alcohol. Most of the striking data is preclinical; human trials are still thin.

1 outlet

Peptide

Livagen

Livagen is a short synthetic peptide (Lys-Glu-Asp-Ala) from the Khavinson family of bioregulator peptides, studied for its intriguing ability to influence gene activity in aging cells. Published work reports that it can decondense tightly packed chromatin and reactivate ribosomal genes in immune cells from elderly donors, a striking demonstration of epigenetic effects from a tiny molecule. For those following the frontier of peptide-based longevity research, Livagen is one of the more thought-provoking bioregulators.

3 outlets

Adaptogen

Milk Thistle

Milk thistle (Silybum marianum) is a flowering plant in the daisy family Asteraceae, recognizable by its spiny leaves veined with white and its purple flower heads. Its seeds yield silymarin, a complex of flavonolignans that has been used in traditional medicine for liver complaints since antiquity. Today milk thistle is marketed chiefly as a herbal dietary supplement, and silymarin remains a focus of research into liver protection.

1 outlet

Peptide

Ovagen

Ovagen is a short peptide bioregulator from the Russian Khavinson tradition, built on the Glu-Asp-Leu (EDL) sequence and directed at the liver and digestive tissue. In the bioregulator model, tiny peptides enter cells and steer tissue-specific gene expression rather than acting on surface receptors, an elegant, low-burden approach that fits naturally into a longevity-minded routine [1][2]. It is a research compound aimed at supporting detoxification, protein synthesis, and healthy cell turnover with age.

4 outlets

Nootropic

SAM-e

SAM-e is a molecule the body already makes from the amino acid methionine; it is the chemical the body uses to hand a methyl group to hundreds of enzymes, which is how it reaches DNA, brain chemicals such as dopamine, and liver metabolism. It is sold as a dietary supplement in the United States and as a prescription drug called ademetionine in Italy, Germany and Russia, mostly for depression, joint pain and liver problems. The evidence is real but genuinely mixed; the Cochrane review of eight trials found the quality too low to draw a conclusion, the largest United States trial found SAM-e no better than placebo, and two separate 2024 meta-analyses of much the same studies reached opposite answers. It is usually well tolerated apart from stomach upset, but it can trigger mania in people with bipolar disorder and should not be combined casually with antidepressants.

4 outlets

Mitochondrial

TUDCA

Tauroursodeoxycholic acid (TUDCA) is a naturally occurring bile acid formed in the body when taurine is joined to ursodeoxycholic acid. It is a water-attracting bile acid present in only small amounts in humans but in large quantities in bear bile, which is why it featured in traditional East Asian medicine. Modern research has examined it as a cell-protective agent, particularly for its ability to reduce cellular stress and blunt programmed cell death in models of liver, metabolic, and neurodegenerative disease.

2 outlets

Bile Acid

UDCA

Ursodeoxycholic acid (UDCA) is a hydrophilic bile acid, originally identified in bear bile, used chiefly to treat primary biliary cholangitis and to dissolve certain cholesterol gallstones. It improves cholestatic liver biochemistry by enriching the bile acid pool with a less cytotoxic, more water-loving species and by protecting cholangiocytes and hepatocytes, while its taurine conjugate acts as a chemical chaperone that relieves endoplasmic reticulum stress and reduces apoptosis. These properties underlie growing interest in UDCA and its conjugates as neuroprotective and metabolic agents, including disease-modifying trials in amyotrophic lateral sclerosis. In a notable repurposing discovery, UDCA was shown to downregulate the SARS-CoV-2 entry receptor ACE2 by inhibiting the farnesoid X receptor, reducing infection across organoids, animals and human tissues; the drug appears on the World Health Organization list of essential medicines.

1 outlet

Terpene

Ursolic Acid

Ursolic acid is a pentacyclic triterpenoid found in the waxy peel of apples and in herbs like rosemary, basil, and holy basil. In rodents it enhances skeletal muscle IGF-1/insulin signaling through Akt, blunts atrophy genes, increases brown fat, and improves glucose tolerance. It also has broad anti-inflammatory and antioxidant activity in cell and animal work. Human data are small and mixed, and oral bioavailability is genuinely poor.

1 outlet

Thyroid

ASC41

ASC41 is an investigational oral prodrug developed by Gannex, a subsidiary of Ascletis Pharma, for non-alcoholic steatohepatitis (NASH, increasingly called MASH). The liver converts it into ASC41-A, a selective agonist of thyroid hormone receptor beta (THR-beta).

reference

Supplement

Silybin

Silybin, also called silibinin, is a flavonolignan that is the principal active constituent of silymarin, a standardized extract of milk thistle (Silybum marianum). It is used and studied mainly for liver protection, including as an intravenous antidote for poisoning by Amanita mushrooms and as an adjunct in chronic liver disease. Its clinical evidence is mixed, and poor water solubility limits the absorption of oral forms.

reference