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Inosine is a purine nucleoside sold across the former Soviet bloc as a cardiac metabolic drug and in the West as a sports supplement; the controlled trials of its ergogenic claim were negative.
- A purine nucleoside feeding the salvage pathway directly
- Sold across the former Soviet bloc as a cardiac metabolic drug
- Raises erythrocyte 2,3-diphosphoglycerate, a real measurable effect
- The neurology work on raising urate is better designed
- Cheap, long established and simple purine chemistry
Mechanism
Inosine feeds the purine salvage pathway and can raise erythrocyte 2,3-diphosphoglycerate, which was the original rationale for expecting better oxygen delivery to working muscle. It is also metabolised to urate, and that urate raising effect is the basis of the separate and better designed work on inosine in Parkinson's disease and multiple sclerosis.
Safetyrisks and cautions, not medical advice
Inosine is a single molecule in the cardiovascular class. A full adverse effect profile has not been compiled for this entry yet, so nothing here should be read as evidence that it is well tolerated; the absence is missing work rather than a finding. What is documented is what the compound is and what it is used for.
Subjective profileweighing the evidence above
As a sports supplement this is a settled question and the answer was no; the controlled trials of the ergogenic claim came back negative and nothing since has revived them. The interesting inosine work is the other one, in neurology, where raising urate is the intended effect rather than a side effect, and that is not what a supplement tub is sold for. Gout, urate stones and impaired kidneys are the clear reasons to stay away, because raising uric acid is the one thing it reliably does.
Where to buy
Suppliers
Vendors carrying Inosine, with live product details and codes. Links are affiliate links that support the wiki at no cost to you.
RUPharma🌐
Inosine