Loading…
for educational and safety purposes
sci-wiki~$open stack esports-reaction-speed
the reaction-time stack in four layers: make the synapse fire faster, hold the attention gate open, sharpen what the eyes send it, and pay for the metabolism that costs
8 items; 8 structures drawn from pubchem.
Reaction time is not one thing, and the reason this roster is coherent rather than a pile of stimulants is that its four layers sit at different points of the same path. Light hits the retina, the signal is cleaned up and sent, a synapse fires, and something has to decide the firing was worth acting on. A stack that only pushes the last step gets a faster twitch and more mistakes.
The centre of it is the AMPA layer. TAK-653 is a positive allosteric modulator, which means it does nothing on its own and only lengthens the channel's open time once glutamate is already there; that is the difference between amplifying a signal and amplifying everything, and it is why the pairing with an attention gate is not redundant. Tropisetron reaches the same synapse from the other side, presynaptically, at alpha-7 rather than AMPA.
Guanfacine is doing the opposite job from the stimulant and that is deliberate. Paraxanthine raises arousal; guanfacine narrows what gets through. Run either alone and the result is worse in a predictable direction, jittery or flat.
The eugeroic arm is an EITHER/OR. Modafinil and flmodafinil do the same job through the same mechanism, and running both is a larger dose of one drug wearing two names.
Lutein and creatine are the two items that are not about a session at all. Both want weeks, both are cheap, and both are better evidenced than anything else on this list.
TAK-653 and tropisetron is the pairing with the clearest rationale, and it is non-redundancy rather than synergy: one is postsynaptic at AMPA, the other presynaptic at alpha-7, so they occupy different sites on the same path. That is a real reason to combine two things and a weaker claim than the word synergy usually carries.
Guanfacine against paraxanthine is the useful tension in the stack. One raises arousal and one raises signal-to-noise, and the combination is what stops the stimulant arm from turning into noise.
Creatine and the rest is ordinary bioenergetics rather than a claim: sustained high-frequency firing costs ATP, and phosphocreatine is the buffer for it.
WHAT HAS ACTUALLY BEEN STUDIED TOGETHER IS ALMOST NONE OF IT. No trial has combined TAK-653 with tropisetron, with guanfacine, or with a eugeroic; the mechanistic story above is a reading of what each does alone. That does not make the combination wrong, and it does make every claim about it a prediction.
The layers arrive on completely different clocks and that is the practical thing to know. Paraxanthine is felt within the hour. Guanfacine is felt as an absence, fewer moments of drifting, and is easy to conclude does nothing; it is also mildly sedating at first and usually settles over a week or two. Lutein and creatine are not felt at all and are judged over weeks by whether performance held up, never by how a session went.
TAK-653 IS INVESTIGATIONAL. There is no approved product, no pharmacy and no supplement form; everything sold under that name is research chemical supply of unverified identity and purity. GUANFACINE IS PRESCRIPTION ONLY, it is a genuine antihypertensive, and the two things it reliably does are lower blood pressure and cause sedation. Stopping it abruptly after regular use can produce rebound hypertension. It is not an item to add to a stack on a whim, and combining it with anything else that lowers blood pressure is the interaction worth checking first. TROPISETRON IS NOT APPROVED IN THE UNITED STATES, and where it is approved it is an antiemetic rather than a cognitive drug. MODAFINIL IS PRESCRIPTION ONLY in most of the world and both it and flmodafinil are banned in competition by WADA and by most tournament organisers that test. If the reason for reading this page is a competitive setting, that is the item to leave out, and the rest of the stack does not depend on it. AND THE INTERACTION ENGINE FLAGS THE STIMULANT ARITHMETIC, WHICH THIS PROSE AGREES WITH RATHER THAN TALKS AROUND. Paraxanthine with either eugeroic is two stimulants, and it adds cardiovascular and jitter load; modafinil with flmodafinil is the same drug twice and is the one pairing here that is simply a mistake. Running a stimulant arm and a eugeroic arm on the same day is also the combination most likely to cost a night's sleep, and sleep is worth more to reaction time than anything on this list.
6 pairs to notecurated roster
3 of 8 in one basketKimera Chems; Code Sean
Guanfacine has no outlet here at all.
5 of 8 priced
3 of these carry no listed price, so there is no honest total to print; the lines above are what can actually be costed.
1 overlapsame lever, twice
interested in protocols? join the discord; that is where dosing, timing and the practical side get discussed.
the sci-wiki publishes this as a description of what these compounds do together, not as a recommendation to take them. Nothing here is medical advice.