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Vialox is a synthetic cosmetic peptide (pentapeptide-3, also called pentapeptide-3V) marketed as a topical "botox-like" muscle-relaxing ingredient. It is described as antagonizing the muscle-type nicotinic acetylcholine receptor, so that fine facial muscles contract less and expression lines appear softened. Its claims are cosmetic and surface-level, not equivalent to injectable treatments.
- Marketed "botox-like" muscle relaxation
- Targets dynamic expression lines
- Generally well tolerated topically
- Non-injectable option
- Possible local irritation
- Redness in sensitive skin
- Rare allergic reaction
Mechanism
Vialox is presented as a competitive at the muscle receptor, reducing acetylcholine-driven activation at the neuromuscular junction and thereby relaxing small facial muscle contractions. In cosmetic use this is proposed to smooth the appearance of dynamic wrinkles from repeated facial movement. As with other cosmetic "neuro-peptides," independent evidence is limited and meaningful systemic absorption from topical application is not expected.
receptor fingerprint
Muscle receptorcompetitive antagonist
Appearance of expression linescosmetic smoothing
Safetyrisks and cautions, not medical advice
As a topical cosmetic peptide, Vialox is generally regarded as low-risk, with possible local irritation, redness, or allergic reaction in sensitive users, so a patch test is reasonable. It is not a drug and should not be expected to produce systemic or true muscle-paralyzing effects from ordinary skincare use. Not medical advice.
Subjective profileweighing the evidence above
Low risk and low reward. It is a topical cosmetic peptide with limited independent evidence, and the botox comparison is marketing; expect a mild softening of expression lines at best. Fine as one ingredient in a serum you already like, not a reason to buy one.
Resources
This entry is here for reference.
Research
- 1.In Vitro and In Silico Assessment of Anticancer Activity of Venom-Derived and Biomimetic Neurotransmitter Inhibitor Pentapeptides
- 2.Integrative In Silico and In Vitro Evaluation of Vialox and Leuphasyl Pentapeptides for Antiaging Applications
2 listed here; entry last updated August 2026
Reviews
My notesprivate to this device
FAQ
What is Vialox?
It is pentapeptide-3, a synthetic cosmetic peptide marketed to relax facial muscle contraction by antagonizing the muscle nicotinic acetylcholine receptor.
Is it as strong as botox?
No; it shares the general concept of muscle relaxation but, as a topical peptide, its effect is cosmetic and far milder than an injectable.
Is it safe on skin?
It is generally low-risk for topical use; patch test first, since irritation or allergy can occur in sensitive people.
Limitations of the evidence
- Limited independent evidence
Adverse effects
- Possible local irritation
- Redness in sensitive skin
- Rare allergic reaction